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AnatomyNeuroanatomyMeninges, ventricular system and subarachnoid space Lateral ventricles
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AnatomyNeuroanatomyMeninges, ventricular system and subarachnoid space Lateral ventricles

Lateral ventricles

Author: Onome Okpe • Reviewer: Ryan Sixtus, MPhEd
Last reviewed: August 08, 2023
Reading time: 9 minutes

Recommended video: Ventricles of the brain [09:39]
Ventricular system of the brain with neighboring structures.
Lateral ventricle (Ventriculus lateralis)

The lateral ventricles are the largest in the series of four interconnecting fluid-filled cavities within the brain. These cavities and their interconnecting channels, constitute the cerebral ventricular system.

The other two cavities of this system are the third and fourth ventricles, while the cerebral aqueduct of Sylvius is one of the interconnecting channels, and it ensures the communication between the third and fourth ventricles. The function of the ventricles is to house the cerebrospinal fluid (CSF) and provide the passage for its circulation.

This article will discuss the anatomy and function of the lateral ventricles.

Contents
  1. Ventricular system
  2. Lateral ventricle
    1. Body
    2. Inferior (temporal) horn
    3. Anterior (frontal) horn
    4. Posterior (occipital) horn
  3. Clinical aspects
  4. Sources
+ Show all

Ventricular system

The ventricular system is a well organized interconnecting system spanning every region of the brain. The channels connecting the lateral ventricles to the third (the midline ventricle) are called the interventricular foramen (or foramen of Monro). The cerebral aqueduct connects the third and fourth ventricles. The system is then made continuous with the central canal of the spinal cord, which originates from the floor of the fourth ventricle.

The ventricles produce and contain cerebrospinal fluid (CSF), and the entire surface of the ventricular system is lined by an epithelial layer called the ependyma. Also, there is a vascular pia mater in the roofs of the third and fourth ventricles, and in the medial wall of the lateral ventricle along the line of the choroid fissure.

This pia mater is directly opposed to the ependyma and forms the tela choroidea, which gives rise to the highly vascularised choroid plexuses. However, the CSF is secreted by the choroid plexuses located within the lateral, third and fourth ventricles alone, but reaches the entire ventricular system and beyond by flowing from the lateral to the third ventricle through the foramen of Monro. It then flows through the cerebral aqueduct into the fourth ventricle, and from there into the central canal starting just inferior to the fourth ventricle. The CSF finally leaves the fourth ventricle through the foramen of Magendie and the foramina of Luschka to reach the subarachnoid space surrounding the brain.

Each lateral ventricle lies within a cerebral hemisphere. The lateral ventricle, when viewed from the lateral aspects of the brain, has a roughly C–shaped profile which follows the arrangement and shape of each hemisphere. Thus, the lateral ventricles span the cerebrum, including the occipital, frontal and parietal lobes. The lateral ventricle has a body or central part and three extensions, namely the anterior, posterior and inferior horns.

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Lateral ventricle

Body

Body of lateral ventricle
Pars centralis ventriculi lateralis
1/2
Synonyms: Central part of lateral ventricle, Corpus ventriculi lateralis

The central part of the lateral ventricle is elongated anteroposteriorly. Anteriorly, it becomes continuous with the anterior horn at the level of the interventricular foramen. Posteriorly, the body reaches the splenium of the corpus callosum.

It is triangular in cross section and has a roof, floor, and a medial wall; the roof and floor meeting on the lateral aspects.

  • The roof is formed by the trunk of the corpus callosum
  • The medial wall is formed by the septum pellucidum and by the body of the fornix, which is common to two lateral ventricles.
  • The floor is formed mainly by the superior surface of the thalamus, medially, and by the caudate nucleus laterally. Between these two structures are the stria terminalis and the thalamostriate veins.

Inferior (temporal) horn

Temporal horn of lateral ventricle
Cornu temporale ventriculi lateralis
1/3
Synonyms: Inferior horn of lateral ventricle, Cornu inferius ventriculi lateralis

The inferior (temporal) horn is the largest component of the lateral ventricle. It begins at the posterior end of the central region, and runs anteroinferiorly into the temporal lobe.

It has an anterior end that reaches close to the uncus of the cerebrum, a floor, and a roof. The roof of the inferior horn is formed mainly by the tapetum of the corpus callosum and the cauda of the caudate nucleus. In cross section, the inferior horn has a narrow cavity which is bounded above, and laterally, by the roof, and below, and medially by the floor. Because of this orientation, the lateral part of the roof is sometimes referred to as the lateral wall, and the medial part of the floor, the medial wall.

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The lateral part of the roof (lateral wall) is formed by fibres of the tapetum, while the medial part of the roof is formed by the tail of the caudate nucleus and the stria terminalis. These structures are continuous into the roof of the inferior horn from the floor of the central part. Anteriorly, the tail of the caudate nucleus and the stria terminalis end in relation to the amygdaloid complex, which lies in the most anterior part of the roof.

The floor of the inferior horn is formed mainly by the hippocampus, along with the alveus and fimbriae. In the lateral part of the floor is an elevation called the collateral eminence, produced by inward bulging of the white mater which lies deep to the collateral sulcus.

Anterior (frontal) horn

Frontal horn of lateral ventricle
Cornu frontale ventriculi lateralis
1/2
Synonyms: Anterior horn of lateral ventricle, Cornu anterius ventriculi lateralis

The anterior (frontal) horn of the lateral ventricle lies anterior to the central part, from which it is separated by an imaginary vertical line that runs at the level of the interventricular foramen. This extension is triangular in cross section and has a roof, floor and medial wall. It is closed anteriorly by the genu and rostrum of the corpus callosum.

Its roof is formed by the most anterior part of the trunk of the corpus callosum, while the floor is formed by the head of the caudate nucleus. A small part of the floor near the midline is formed by the upper surface of the rostrum of the corpus callosum. The medial wall is formed by the septum pellucidum.

Posterior (occipital) horn

Occipital horn of lateral ventricle
Cornu occipitale ventriculi lateralis
1/3
Synonyms: Posterior horn of lateral ventricle, Cornu posterius ventriculi lateralis

The posterior (occipital) horn of the lateral ventricle extends posteromedially into the occipital lobe, and like other parts of the lateral ventricle it has a roof, lateral wall and a medial wall.

The roof and lateral wall are formed by the tapetum, while the medial wall shows two elevations, one superior and the other inferior and referred to as the calcar avis. Superior to those elevations is a structure called the bulb of the posterior horn. This bulb is formed by fibres of the forceps major as they run backwards from the splenium of the corpus callosum.

Solidify your knowledge with our quiz about the ventricles of the brain:

Clinical aspects

Ventriculomegaly is a condition in which the lateral ventricle becomes abnormally enlarged. It is closely associated with mental disorders such as the brain pressure inducing hydrocephalus, Alzheimer’s disease, dementia, schizophrenia, and bipolar disorder, as well as movement disorders like as Parkinson’s disease and Huntington’s disease.

The cause of ventriculomegaly is largely unknown, but it is highly speculated that atrophy of structures surrounding the lateral ventricles may be the major contributing factor, as well as a reduction in the size of the surrounding periventricular structures which allows the ventricles to expand and fill in the space.

Another possible cause could be blockage of venous blood or CSF flow that increases CSF volume in the ventricles. Another possible cause is from mechanical compression and shear stresses that result in damage and atrophy of nearby structures that surround the ventricles.

Some of the suspected causes of the compression and shear stresses are blockage of venous blood and CSF flow, venous back pressure, abnormal pressure waves and pounding type waves, called water hammers.

Sources

All content published on Kenhub is reviewed by medical and anatomy experts. The information we provide is grounded on academic literature and peer-reviewed research. Kenhub does not provide medical advice. You can learn more about our content creation and review standards by reading our content quality guidelines.

References:

  • S. Standring: Gray’s Anatomy – The Anatomical Basis of Clinical Practice, 40th edition, (2008), p. 237- 238, 240 – 244.
  • S. Vishram: Text book of Clinical Neuroanatomy, 2nd edition, (2010) p.120 – 123.

Illustrators:

  • Left lateral ventricle (lateral view) - Paul Kim
  • Choroid plexus (coronal view) - Paul Kim
  • Body of lateral ventricle (lateral view) - Paul Kim
  • Inferior horn of lateral ventricle (lateral view) - Paul Kim
  • Anterior horn of lateral ventricle (lateral view) - Paul Kim
  • Posterior horn of lateral ventricle (lateral view) - Paul Kim

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