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HistologyTypes of tissuesNervous tissuePerineurium
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HistologyTypes of tissuesNervous tissuePerineurium

Perineurium

Author: Danijel Tosovic, PhD • Reviewer: Dimitrios Mytilinaios, MD, PhD
Last reviewed: March 18, 2024
Reading time: 1 minute

Recommended video: Peripheral nerves [16:31]
Histological appearance of the peripheral nerves.
Perineurium
1/3
Synonyms: none

The perineurium is a thin layer of connective tissue that surrounds an individual nerve fascicle, which is a group of neuronal axons. It is the middle of the three connective tissue layers of peripheral nerves, with the innermost being the endoneurium surrounding individual axons, and the outermost being the epineurium surrounding the entire nerve (all nerve fascicles bundled together). 

The perineurium consists of layers of flattened fibroblastic polygonal cells and collagen fibers enclosed by a basal lamina. It is metabolically active diffusion border and an effective barrier against foreign substances. 

Terminology English: Perineurium
Latin: Perineurium
Definition Connective tissue layer surrounding individual nerve fascicles
Function Protects nerve fibers, is a metabolically active diffusion border, maintains homeostasis of endoneurium

Take a closer look at the components of peripheral nerves in this study unit (and article):

Peripheral nerves Explore study unit
Peripheral nerves histology Read article

Sources

All content published on Kenhub is reviewed by medical and anatomy experts. The information we provide is grounded on academic literature and peer-reviewed research. Kenhub does not provide medical advice. You can learn more about our content creation and review standards by reading our content quality guidelines.
  • Moore, K. L., Dalley, A. F., & Agur, A. M. R. (2014). Clinically Oriented Anatomy (7th ed.). Philadelphia, PA: Lippincott Williams & Wilkins.
  • Standring, S. (2016). Gray's Anatomy (41st ed.). Edinburgh: Elsevier Churchill Livingstone.

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