The fibroblast is the most abundant cell of the connective tissue. It appears a fusiform, spindle-shaped cell with an oval euchromatic nucleus, large amounts of rough endoplasmic reticulum and a well-developed Golgi apparatus.
The fibroblast represents the synthetically active form of the fibrocyte, which is the smaller inactive state of the cell, containing a flattened heterochromatic nucleus, and less cytoplasm and cellular organelles.
Fibroblasts synthesize and secrete the extracellular matrix (ECM) proteins, particularly collagen and elastin, that are used to maintain a structural framework in many tissues. In addition, some fibroblasts, referred to as myofibroblasts, have contractile properties and play a critical part in wound healing.
|Definition||Fibroblasts are the permanent residents of connective tissue that produce and secrete the extracellular matrix.|
Fibroblast: Synthetically active state
Fybrocyte: Synthetically inactive state
|Function||Production of collagen, elastin and other ECM proteins
Wound healing and scar formation (myofibroblasts)
Check out the study unit below to more about the role of fibroblasts in the dense connective tissue!
Fibroblast: want to learn more about it?
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