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Fibroblast
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:watermark(/images/watermark_only_413.png,0,0,0):watermark(/images/logo_url_sm.png,-10,-10,0):format(jpeg)/images/anatomy_term/fibrocytes/Nc1vjE7hZKTsKO2RLvUog_Fibrocytes1.png "Fibrocyte (Fibrocytus); Image:"){kind=logo}
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The fibroblast is the most abundant cell of the connective tissue. It appears a fusiform, spindle-shaped cell with an oval euchromatic nucleus, large amounts of rough endoplasmic reticulum and a well-developed Golgi apparatus.
The fibroblast represents the synthetically active form of the fibrocyte, which is the smaller inactive state of the cell, containing a flattened heterochromatic nucleus, and less cytoplasm and cellular organelles.
Fibroblasts synthesize and secrete the extracellular matrix (ECM) proteins, particularly collagen and elastin, that are used to maintain a structural framework in many tissues. In addition, some fibroblasts, referred to as myofibroblasts, have contractile properties and play a critical part in wound healing.
| Definition | Fibroblasts are the permanent residents of connective tissue that produce and secrete the extracellular matrix. |
| Origin | Mesenchymal cells |
| States |
Fibroblast: Synthetically active state Fybrocyte: Synthetically inactive state |
| Function | Production of collagen, elastin and other ECM proteins Wound healing and scar formation (myofibroblasts) |
Check out the study unit below to more about the role of fibroblasts in the dense connective tissue!
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