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HistologyBody systemsFemale reproductive systemPerimetrium
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HistologyBody systemsFemale reproductive systemPerimetrium

Perimetrium

Author: Christina Loukopoulou, MSc • Reviewer: Dimitrios Mytilinaios, MD, PhD
Last reviewed: March 19, 2024
Reading time: 2 minutes

Recommended video: Uterus [06:13]
Anatomy and function of the uterus.
Perimetrium
1/2
Synonyms: Serosa of uterus, Serous coat of uterus , show more...

The perimetrium is one of three layers of the uterine wall, with the myometrium and the endometrium being the other two.

It is the outermost layer and is structurally derived from the peritoneum. The perimetrium envelops most of the uterine surfaces up to the junction where the body of the uterus meets the cervix.

Histologically, it is made up of a thin layer of connective tissue covered by a layer of simple squamous epithelium. This epithelial layer serves as a barrier protecting the uterus from infections and other harmful pathogens.

Apart from fulfilling protective functions, it helps to maintain the structural integrity of the uterus in addition to anchoring to neighbouring structures of the pelvis such as the broad ligament of uterus and the pelvic floor.

Interestingly, the perimetrium is involved in the menstrual cycle. It responds to hormonal changes by thickening and thinning to help prepare the uterus for the implantation of a fertilized egg.

Terminology English: Perimetrium
Synonyms: Serosa of uterus, Serous coat of uterus

Latin: Perimetrium
Synonym: Tunica serosa uteri
Definition The perimetrium is the outermost layer of the uterine wall.
Function Protection agains infection, maintaining structural integrity of uterus, menstrual cycle.

Learn more about the histological structure of the uterine wall in the following study unit:

Uterine wall Explore study unit

Sources

All content published on Kenhub is reviewed by medical and anatomy experts. The information we provide is grounded on academic literature and peer-reviewed research. Kenhub does not provide medical advice. You can learn more about our content creation and review standards by reading our content quality guidelines.
  • Moore, K. L., Dalley, A. F. and Agur, A. (2017). Clinically oriented anatomy (8th ed.). Lippincott Williams and Wilkins.
  • Ross, M. H. Pawlina, W. (2011). Histology : a text and atlas : with correlated cell and molecular biology (6th ed.). Wolters Kluwer/Lippincott Williams & Wilkins Health.
  • Standring, S. (2016). Gray's Anatomy (41st ed.). Edinburgh: Elsevier Churchill Livingstone.

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