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AnatomyBasicsIntroduction to the musculoskeletal systemPerimysium
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AnatomyBasicsIntroduction to the musculoskeletal systemPerimysium

Perimysium

Author: Edwin Ocran, MBChB, MSc • Reviewer: Dimitrios Mytilinaios, MD, PhD
Last reviewed: October 30, 2023
Reading time: 2 minutes

Recommended video: Skeletal muscle tissue [12:25]
This type of tissue is found in skeletal muscles and is responsible for the voluntary movements of bones.
Perimysium
1/3
Synonyms: Interfascicular connective tissue, Textus connectivus interfascicularis

The perimysium also called interfascicular connective tissue, is a connective tissue sheath that surrounds individual muscle fascicles (bundles of muscle fibers), and separates them from other fascicles within the skeletal muscle.

The perimysium is made up of dense irregular connective tissue which contains mainly type I and type III collagen. It is continuous with the endomysium that wraps around individual muscle fibers, and the epimysium which encloses the entire muscle.

It contains a rich network of blood vessels and nerves, known as the neurovascular bundles, that branch out to supply muscle fibers of each fascicle with nutrients and oxygen, while also facilitating signal transmission.

During muscle contraction, the perimysium transmits the force produced by individual muscle fibers across the fascicles, generating smooth, coordinated muscle contraction and movements.

Terminology English: Perimysium
Synonym: Interfascicular connective tissue

Latin: Perimysium
Synonym: Textus connectivus interfascicularis
Definition Fibrous sheath envelopes each fascicles (muscle bundle) of skeletal muscle.
Structure Dense irregular connective tissue; predominantly type I and type III collagen
Function Transmission of contraction forces, transmission of neuronal signals to muscle fibers, delivery of nutrients and oxygen to muscle fibers

Learn more about skeletal muscles in this study unit:

Skeletal muscle Explore study unit

Sources

All content published on Kenhub is reviewed by medical and anatomy experts. The information we provide is grounded on academic literature and peer-reviewed research. Kenhub does not provide medical advice. You can learn more about our content creation and review standards by reading our content quality guidelines.

References:

  • McKinley, M. & Loughlin, V. (2012). Human anatomy. New York: McGraw-Hill.
  • Mescher, A. L., & Junqueira, L. C. (2013). Junqueira's basic histology: Text & atlas. McGraw-Hill Medical.
  • Ross, M. H., & Pawlina, W. (2011). Histology : a text and atlas : with correlated cell and molecular biology (6th ed.). Wolters Kluwer/Lippincott Williams & Wilkins Health
  • Young, B., O'Dowd, G., & Woodford, P. (2014). Wheater's functional histology: A text and colour atlas. Churchill Livingston/Elsevier.

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