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Clinical case: Sister Mary Joseph nodule: want to learn more about it?

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Clinical case: Sister Mary Joseph nodule

This article is about a woman which presented with a firm, nontender, and protruberant umbilical nodule, classically called the Sister Mary Joseph nodule. Do you know what can cause its appearance on a patient? Stick around to find out more about this woman's condition, her final diagnosis, treatment, and relevant anatomical considerations.

Key facts
CA125 It is a tumor marker, especially prevalent in ovarian cancer cells. The normal blood value is 0 to 21 units/mL.
Omental metastases These metastases spread via the omentum, especially through the falciform and medial umbilical ligaments, both remnants of embryological structures.
Vesicouterine pouch A shallow peritoneal recess between the uterus and the urinary bladder, which can be used as a landmark for chronic endometriosis.
Rectouterine pouch A shallow peritoneal recess between the rectum and the uterus, which can be a common site for the spread of ascites, tumors, endometriosis.
Omental cake It refers to infiltration of the omental fat by material of soft-tissue density, such as cancer cells. It is readily seen radiologically.

After reviewing this case you should be able to describe the following:

  • What the significance is of a CA125 level. What the normal levels of this protein are.
  • What is meant by omental metastases? The radiological term associated with omental metastases.
  • The clinical significance of the vesicouterine and rectouterine pouch (of Douglas).
  • The embryological remnants that possibly provide a mechanism whereby metastases could spread from the ovaries or abdominal viscera to the umbilicus.

This article is based on a case report published in the Journal "Case Reports in Surgery" in 2015, by Caroline C. Jadlowiec, Beata E. Lobel, Namita Akolkar, Michael D. Bourque, Thomas J. Devers, and David W. McFadden.

Historical prelude

Sister Mary Joseph nodule (SMJN) is an uncommon umbilical lesion occurring as a result of an intra-abdominal and/or pelvic malignancy. The nodule was named after Sister Mary Joseph, a surgical assistant to Dr. William J. Mayo at the Mayo Clinic (1890-1915). Sister Mary observed the association between the presence of an umbilical nodule and an intra-abdominal malignancy. Such a nodule may also occur with ovarian and uterine cancer. The mechanism of tumor dispersion to the umbilicus is poorly understood and could be via lymphatic, vascular, contiguous, or embryologic remnant spread.

Case description

History and physical exam

A 76-year-old female had a one-month history of a rapidly enlarging and friable umbilical tumor. She presented to the hospital for a surgical consultation. The patient had a history of hypertension, hyperlipidemia, and tubal ligation. Physical examination revealed a 2 cm firm, nontender, protuberant umbilical nodule (Figure 1).

Figure 1. The umbilical nodule.

Investigations

The patient initially was diagnosed with telangiectatic granuloma and was treated with topical antibiotics; however, after two months the patient did not show any improvement. Her physicians then suspected that she had a malignant umbilical tumor; blood tests were ordered and revealed high levels of CA125 (over 500 U/mL). An upper and lower gastroenterological endoscopy was then done and showed no major abnormalities. However, a transvaginal ultrasound revealed a 2 cm ovarian cyst.

Figure 2. T1 MRI showing ovarian and umbilical tumors. The blue arrow indicates that this patient also had a herniated L4/5 intervertebral disk. For this patient, this latter finding would be noted on the radiological report but would be considered an incidentaloma. That is, such a finding is “incidental” to the purpose of the radiologic procedure, in this case the MRI procedure to identify primary cancer. For the healthcare system however, the findings of incidentalomas have significance because once found, they are often treated even if the patient was not complaining of the condition associated with the lesion, in this case likely back pain. So because of the finding of a herniated disk, the patient may have sought medical care such as physical therapy to ameliorate the condition. 

Imaging by CT and MRI confirmed the presence of the mass and revealed intra-abdominal and right lung metastatic lesions (Figures 2-4).

Figure 3. Axial MRI showing an intra abdominal mass, most likely a metastasis.

Because of the likely diagnosis of metastatic ovarian cancer, an exploratory laparotomy was performed. A cystic mass of approximately 2-3 cm was observed on the right ovary and a small amount of ascites was noted (Figure 5).

Figure 4. Axial contrast-enhanced CT through the thorax showing a tumor in the right upper lung. Note that this CT is done with a lung “window” setting, which maximizes the different CT densities in the lung but minimizes the difference in other tissues. 

Further, intra-abdominal and omentum metastatic lesions as large as 5 cm were identified. Millet-seed sized lesions (about 3 mm) were observed in the walls of the uterus and in the vesico-uterine and recto-uterine (of Douglas) pouches (Figure 6).

Figure 5. Intraoperative image of the ovarian tumor.

Diagnosis and management

Because it was impossible to remove all the metastatic lesions, a bilateral salpingo-oophorectomy, and umbilical and omentum tumor resections were performed. The histopathological analysis indicated that the primary tumor was an ovarian serous adenocarcinoma. Accordingly, the conclusive diagnosis was a stage IV ovarian cancer.

The patient’s postoperative course was uneventful. She was discharged 10 days after surgery. Chemotherapy was started one month after hospital discharge. At the time of the writing of the case report, the patient was having monthly follow-ups with blood tests (tumor markers) and vaginal ultrasounds.

Figure 6. DIssection image (from a superior view) showing the adnexa and the recto-uterine and vesico-uterine pouches. Note the nodular nature of the ovary in this cadaver. These nodules are likely cysts or the remnants of ovarian cysts. 

Surgical and anatomical considerations

Umbilical tumors are rare. Benign etiology includes umbilical hernia, granuloma, abscess, mycosis, and eczema. Malignant tumors can be either primary or metastatic. The appearance of an SMJN can be markedly variable, ranging from a hard and irregular nodule to a soft and painful ulcerated mass (see Figure 7 for a different patient with a SMJN nodule). 

Figure 7. Axial CT from a different patient with a SMJN lesion showing metastatic tumor in the umbilicus. 

Upon physical examination, a SMJN’s appearance is often misleading because the skin overlying the lesion can be normal or erythematous. Because other symptoms were not observed in this patient, the first diagnosis was a granuloma and it took an additional two months of ineffective treatments before a malignant umbilical tumor was suspected. A biopsy might have decreased the time to diagnosis but the patient declined because of the risk of bleeding from the umbilical tumor. Although SMJN is typically associated with gastrointestinal malignancies, in this case both upper and lower endoscopies did not provide a source of the tumor. However, a vaginal ultrasound did.

The final pathological designation was an ovarian serous adenocarcinoma with intra-abdominal and thoracic metastases. SMJN usually represents a late manifestation of metastatic disease. Adenocarcinoma is a type of cancer that can occur in various regions of the body. It originates in glandular tissues. The umbilicus is a prominent feature of the human abdominal wall, typically located at the L3/L4 vertebral level. 

The skin of the umbilicus is supplied by the tenth thoracic spinal nerve and thus in this patient that nerve was likely the one that was conducting the patient’s pain (T10 dermatome). It is important to note anatomical landmarks that are indicative of vertebral levels so that surgical procedures can be planned effectively but also be aware that body habitus can modify these relationships. Thus, for this patient, location of the umbilicus is at the normal L4 vertebral body level; however in obese patients the umbilicus can be as low as sacral levels. Pertaining to sensory innervation, the T10 dermatome is associated with the umbilicus. Spinal nerves and associated dermatomes follow an obliquely inferior path as they travel from posterior to anterior; they thus do not follow a path parallel to the ground (or axial plane).

Clinical case: Sister Mary Joseph nodule: want to learn more about it?

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“I would honestly say that Kenhub cut my study time in half.” – Read more. Kim Bengochea Kim Bengochea, Regis University, Denver

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