EN | DE | PT Contact How to study Login Register

Breast - want to learn more about it?

Our engaging videos, interactive quizzes, in-depth articles and HD atlas are here to get you top results faster.

Sign up for your free Kenhub account today and join over 960,586 successful anatomy students.

“I would honestly say that Kenhub cut my study time in half.” – Read more. Kim Bengochea Kim Bengochea, Regis University, Denver


The breasts, also referred to as mammary glands (Latin: mammae) are the most prominent superficial structures in the anterior thoracic wall, especially in women. It is an organ found in both males and females, but its mammary glands, which are accessory to reproduction in the adult females, are rudimentary and functionless in men and consist of only a few small ducts or epithelial cords. The mammary glands are in the subcutaneous tissue overlying the pectoralis major and minor muscles.

The amount of fat surrounding the glandular tissue determines the size of non-lactating breasts. Usually, the fat present in the male breast is not different from that of subcutaneous tissue elsewhere in the body, and the glandular system does not normally develop. At the greatest prominence of the breast is the nipple, surrounded by a circular pigmented area of skin called the areola (Latin: small area).

Key facts about the breast
Development From 4th week
Relations & location

Surface anatomy - Second to sixth ribs, lateral border of sternum to midaxillary line

Relations - Pectoralis major, serratus anterior, rectus sheath, external oblique muscle, retromammary space (bursa), axillary fossa

Structure Suspensory ligaments, mammary gland lobules, areola, nipple, lactiferous ducts, lactiferous sinus
Blood supply

Lateral thoracic artery

Internal thoracic artery 

Thoracoacromial artery

Venous drainage

Axillary veins

Pposterior intercostal veins

Lymphatic drainage Subareolar lymphatic plexus; axillary, internal thoracic, and infraclavicular lymph nodes
Innervation Cutaneous branches of the fourth to sixth intercostal nerves
Clinical aspects Mastectomy, gynecomastia

Embryonic Development

The breast is a modified apocrine sweat gland and begins to develop as early as the 4th week as a downgrowth from a thickened mammary ridge (milk line) of ectoderm along a line from the axilla to the inguinal region. Supernumerary nipples or even glands proper may form at lower levels on this line.

Gross Features of the Breast

Location & Relations

Despite individual variations in size, the extent of the base of the breast is fairly constant: from nearly the midline to near the midaxillary line, and from the 2nd to the 6th ribs. It overlies pectoralis major muscle, overlapping on to serratus anterior muscle and to a small part of rectus sheath and external oblique muscle.

Breast - ventral view

The roughly circular body of the breast (female breast) rests on a bed that extends transversely from the lateral border of the sternum to the midaxillary line, and from the 2nd to 6th ribs, and thus roughly spans the area on which the base of the breast sits. Two thirds of the bed of the breast are formed by the pectoral fascia overlying the pectoralis major muscle; the other third, by the fascia covering the serratus anterior muscle.

Recommended video: Female breast structure
Structures of the female breast seen on a sagittal section and anterolateral view.

Between this pectoral fascia and the breast is a loose connective tissue plane or potential space called the retromammary space (bursa). This plane, containing a small amount of fat, allows the breast some degree of movement on the pectoral fascia. A small part of the upper outer quadrant of the mammary gland may extend along the inferolateral edge of the pectoralis major toward the axillary fossa (armpit), forming an axillary tail or process (of Spence). This axillary tail is not always present, but when present, lies in the medial wall of the axilla and may be a discrete mass poorly connected with the duct system. Some women discover the axillary process (especially when it may enlarge during a menstrual cycle) and become concerned that it may be a lump (tumor) or enlarged lymph nodes.

Suspensory ligaments of breast - lateral-left view


The mammary gland is firmly attached to the dermis of the overlying skin, especially by substantial skin ligaments called the suspensory ligaments (of Cooper). These condensations of fibrous connective tissue, particularly well developed in the superior part of the gland, help support the mammary gland lobules. During puberty (ages 8-15 years in both sexes), the breasts normally enlarge, owing in part to glandular development but primarily from increased fat deposition. The areolae and nipples also enlarge. Breast size and shape are determined by genetic, ethnic, and dietary factors.

The lactiferous ducts give rise to buds that form 15-20 lobules of glandular tissue, which constitute the parenchyma of the mammary gland. Each lobule is drained by a lactiferous duct, which usually opens independently on the nipple. The lactiferous ducts branch off in a radial direction towards the nipple like the spokes of bicycle wheel.

Deep to the areola, each duct has a dilated portion, the lactiferous sinus, in which a small droplet of milk accumulates or remains in the nursing mother. As the infant begins to suckle, compression of the areola (and the lactiferous sinus beneath it) expresses the accumulated droplets and encourages the infant to continue nursing as the hormonally mediated let-down reflex ensues and the mother’s milk is secreted into – not sucked from the gland by – the baby’s mouth.

The areola contain numerous sebaceous glands, which enlarge during pregnancy and secrete an oily substance that provide a protective lubricant for the areola and nipple, which are particularly subject to chaffing and irritation as mother and baby begin the nursing experience. Some large sebaceous or areola glands may form small elevations called tubercles of Montgomery.

The nipples are conical or cylindrical prominences in the centre of the areola. The nipples have no fat, hair or sweat glands. The tips of the nipples are fissured with the lactiferous ducts opening into them. The nipples are composed mostly of circularly arranged smooth muscles fibres that compress the lactiferous duct during lactation and erect the nipples in response to stimulation as when a baby begins to suckle. In most women, the breast enlarge slightly during the menstrual period from increased release of the gonadotropic hormones – follicle stimulating hormone (FSH) and luteinizing hormone (LH) – on the glandular tissue. For the anatomical location and description of tumors and cysts, the surface of the breast is divided into four quadrants.

Blood Supply

The breast is supplied by three main arteries which form anastomosing network. The arteries are the: 

  • lateral thoracic artery
  • internal thoracic artery
  • thoracoacromial artery

The lateral thoracic sends branches that curl around the border of pectoralis major and other branches that pierce the muscle. The internal thoracic artery also sends branches through the intercostal spaces beside the sternum; those of the 2nd and 3rd spaces are the largest. Similar but small perforating branches arise from the intercostal arteries. Pectoral branches of the thoracoacromial artery supply the upper part of the breast.

Venous Drainage

The venous drainage of the breast is mainly by deep veins that run with the main arteries to internal thoracic artery and by the axillary veins. Some drainage to posterior intercostal veins provides an important link to vertebral veins and hence a pathway to metastatic spread to the vertebral bones. Superficial veins may anastomose across the midline (though not all authorities subscribe to this suggestion).

Axillary vein - ventral view

Lymph Drainage

The lymphatic system of the breast is very important in relation with the spread of malignant disease. There are numerous lymphatic capillaries in the breast. Lymph passes from the nipple, areola and lobules of the gland to a lymphatic plexus called the subareolar lymphatic plexus and from this plexus, lymph (over 75%) from the lateral part of the breast (upper and lower outer quadrants) drains into the axillary and infraclavicular lymph nodes.

Recommended video: Lymphatics of the female breast
Lymph vessels and nodes of the female breast.

Lymph from the rest part of the breast, that is, from the medial part (upper and lower inner quadrants) drains through the intercostal spaces into the internal thoracic (parasternal) lymph nodes.


The overlying skin of the breast is supplied by the cutaneous branches of the 4th-6th intercostal nerves (T4-T6). Sympathetic fibres supply the blood vessels and glands, but the control of lactation is hormonal.

Clinical Notes


The extensive removal of the breast and adjacent tissues for carcinoma which was very common in earlier decades has now given place in many cases to local excision supplemented by radiotherapy and chemotherapy. If simple mastectomy is required, the breast is stripped-off the pectoralis fascia and adjacent muscles, together with axillary fat and lymph nodes. For more radical procedures, one or both pectoral muscles can be removed as well. Also, most women with single breast cancers up to 4 cm in diameter are treated by breast conservation rather than masectomy. Furthermore, when masectomy is necessary, there are three levels of disection depending on severity.

Changes in the Breast

Changes such as branching of the lactiferous duct occur in the breast tissue during menstrual periods and in pregnancy. Although mammary glands are prepared for secretion by mid-pregnancy, they do not produce milk until shortly after the baby is born. Colostrum, a creamy white to yellowish pre-milk fluid, may secrete from the nipples during the last trimester of pregnancy and during initial episodes of nursing. Colostrum is believed to be especially rich in protein, immune agents and a growth factor affecting the infant’s intestines. In multiparous women, the breast often becomes large and pendulous. The breasts in elderly women are usually small because of the decrease in fat and the atrophy of glandular tissue.


Gynecomastia is swelling of the breast tissue in boys or men, caused by an imbalance of the hormones estrogen and testosterone. Slight temporary enlargement of the breast is a normal occurrence with a frequency of 70% in males at puberty. Breast hypertrophy in males after puberty is relatively rare, and may be age related or drug related, for example the use of anabolic steroids.

Gynecomastia may also result from an imbalance between estrogenic and androgenic hormones or from a change in the metabolism of sex hormones by the liver. It can affect one or both breasts, sometimes unevenly. Newborns, boys going through puberty and older men may develop gynecomastia as a result of normal changes in hormone levels. Generally, gynecomastia is not a serious problem, but it can be tough to cope with the condition. Men and boys with gynecomastia sometimes have pain in their breasts and may feel embarrassed. Gynecomastia may go away on its own. If it persists, medication or surgery may help.

Breast - want to learn more about it?

Our engaging videos, interactive quizzes, in-depth articles and HD atlas are here to get you top results faster.

Sign up for your free Kenhub account today and join over 960,586 successful anatomy students.

“I would honestly say that Kenhub cut my study time in half.” – Read more. Kim Bengochea Kim Bengochea, Regis University, Denver

Show references


  • Last's Anatomy (Regional and Applied), 9th Edition, (2014), p. 70 -72.
  • K. L. Moore and A. F. Dalley: Clinically oriented anatomy, 5th edition, (2006), p. 105 – 111.

Author, Review and Layout:

  • Onome Okpe
  • Ryan Sixtus
  • Catarina Chaves


  • Breast - ventral view - Irina Münstermann
  • Suspensory ligaments of breast - lateral-left view - Samantha Zimmerman
  • Lobules of mammary glands - ventral view - Samantha Zimmerman
  • Lactiferous duct and sinus - lateral-left view - Samantha Zimmerman
  • Areola - ventral view - Irina Münstermann
  • Lateral mammary branches of lateral thoracic artery - ventral view - Samantha Zimmerman
  • Axillary vein - ventral view - Samantha Zimmerman
© Unless stated otherwise, all content, including illustrations are exclusive property of Kenhub GmbH, and are protected by German and international copyright laws. All rights reserved.

Related diagrams and images

Continue your learning

Read more articles

Show 5 more articles
Well done!

Register now and grab your free ultimate anatomy study guide!

Create your free account.
Start learning anatomy in less than 60 seconds.