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Sigmoid colon

The sigmoid colon is part of the hindgut. It is the last part of the colon before the rectum. It acts as a site for water absorption from the faeces, as a site for flatus to be stored before being expelled, and as a site of peristalsis.

In this article we will discuss the anatomy of the sigmoid colon including its blood supply, venous drainage, lymphatic drainage, and nerve supply. We conclude the article with relevant clinical aspects about the sigmoid colon.

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Structure of the large intestine, including the mucosa and musculature.


sigmoid colon in situ ventral view

Sigmoid colon - ventral view

The gastrointestinal system is divided into the foregut, midgut and hindgut. The foregut stretches from the oesophagus to the major duodenal papilla, the midgut from the major duodenal papilla to two thirds of the transverse colon, and the hindgut from this point to the pectinate line of the rectum.


The hindgut gets its blood supply from the inferior mesenteric artery, its parasympathetic nerve supply from the pelvic splanchnic nerves (S2-S4), and its sympathetic innervation from the lumbar splanchnic nerves (L1-L2). The cell bodies of the pelvic splanchnic nerves can be found in the sacral parasympathetic nucleus. Most preganglionic parasympathetic neurones synapse in the wall of the hindgut, while postganglionic neurones innervate glands and muscle to increase colonic motility and to relax the internal anal sphincter. Lumbar splanchnic nerves synapse in the abdominal aortic and inferior mesenteric plexuses to allow postganglionic sympathetic fibres to slow colonic motility and contract the internal anal sphincter. The autonomic nervous system modulates the activity of the enteric nervous system innervating the large intestine, which includes motor and sensory neurones. Meissner’s plexus can be found in the submucosa, while Auerbach’s myenteric plexus lies between the longitudinal and circular smooth muscle layers of the gut wall. Both plexuses contain interstitial cells of Cajal, which generate the pacemaker activity of the gut essential for peristalsis. Finally, visceral afferents relay the sensation of colonic distension.

large intestine excised with sigmoid colon highlighted

Large intestine excised with sigmoid colon highlighted


The S-shaped sigmoid colon is part of the hindgut and is the last region of the large bowel before the rectum. It begins around the superior aperture of the pelvis, and is continuous with the descending colon. The sigmoid colon curves back on itself, and descends into the pelvis. It is intraperitoneal (unlike the rectum, ascending and descending colon, which are retroperitoneal) and is covered in mesentery, i.e. the sigmoid mesocolon. The mesentery is long in the center of the sigmoid colon, allowing it a significant range of mobility. The lower part of the mesentery is shorter, meaning the rectum and descending colon are relatively stable. As soon as the mesentery (sigmoid mesocolon) stops, the bowel is renamed the rectum (which is retroperitoneal). It runs deep to the lesser (or true) pelvis, together with the bladder.

It runs in front of the sacrum, external iliac vessels, the left sacral plexus, left ureter, and the left piriformis muscle (a pear shaped external hip rotator that divides the greater sciatic foramen into two openings). It also lies anterior to the posterior abdominal wall (quadratus lumborum, iliacus, iliac crest). Laterally is the vas deferens/ovary. Superior to it are loops of the ileum, and anterior to it are the bladder and uterus (in the female).

The sigmoid colon usually lies within the pelvis, but can be displaced into the abdomen due to its relatively mobile nature. The sigmoid colon receives its blood supply from the two to five sigmoidal branches of the inferior mesenteric artery, which is a branch of the abdominal aorta at L3. The venous drainage of the sigmoid colon follows the arterial supply and venous blood is drained by the inferior mesenteric vein. Lymphatic drainage follows the course of the inferior mesenteric vessels.

Clinical Points

Diverticulitis- A diverticulum is an outpouching of the wall of the bowel, and most frequently occurs in the sigmoid colon. It usually occurs due to chronic constipation from a high fat, low fiber diet. If a faecolith is trapped in one of these herniations, or becomes infected, the patient will present with left iliac fossa pain. They may present with blood in the faeces. The condition most frequently occurs in the elderly.

Sigmoid volvulus- Volvulus is when the bowel twists on itself, closing the lumen. It is more likely to occur when the sigmoid colon and its mesocolon are long. This results in pain and absolute constipation. If volvulus remains for a significant period, the bowel may become ischaemic and necrotic, risking peritonitis. The coffee bean sign on an abdominal x-ray can identify sigmoid volvulus. Treatment includes analgesia and immediate surgery to correct the volvulus and any underlying anatomical defect that may have given rise to the condition. Volvulus in children is more likely to occur following rotation of the midgut.

Crohn’s colitis- This in an inflammatory bowel condition that can affect any part of the gastrointestinal tract, from the mouth (where it causes aphthous ulcers) to the small bowel, large bowel and rectum. Symptoms include diarrhoea, weight loss and associated skin changes. The disease has a number of extraintestinal manifestations, such as arthritis, anterior uveitis (inflammation of the anterior chamber of the eye), pyoderma gangrenosum (pustular skin changes on the legs), erythema nodosum (purplish marks on the legs), and gallstones. The condition is worsened by smoking.

Ulcerative colitis- This is an autoimmune inflammatory bowel condition that begins at the rectum and tracks proximally. Symptoms include bloody diarrhoea and weight loss. Anterior uveitis (inflammation of the anterior chamber of the eye), pyoderma gangrenosum (pustular skin changes on the legs), erythema nodosum (purplish marks on the legs). The condition is improved by smoking, and is associated with primary sclerosing cholangitis, cholangiocarcinoma and bowel cancer.

Sigmoid colectomy- This is a procedure involving the removal of the sigmoid colon. It is utilised for crohn’s disease, bowel cancer or diverticular disease.The sigmoid colon is excised leaving a rectal stump. The descending colon is then anastomosed to the rectal stump ensuring continuity of the bowel, and maintained continence.

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Show references


  • Frank H.Netter MD: Atlas of Human Anatomy, 5th Edition, Elsevier Saunders.
  • Chummy S.Sinnatamby: Last’s Anatomy Regional and Applied, 12th Edition, Churchill Livingstone Elsevier.
  • Richard L. Drake, A. Wayne Vogl, Adam. W.M. Mitchell: Gray’s Anatomy for Students, 2nd Edition, Churchill Livingstone Elsevier.
  • Jones J, MD and Knipe H, MD: Sigmoid colon. (accessed 26/02/2016).
  • Thoracic splanchnic nerves. (accessed 26/02/2016).

Author, Review and Layout:

  • Shahab Shahid
  • Jérôme Goffin
  • Catarina Chaves


  • Sigmoid colon - ventral view - Irina Münstermann
© Unless stated otherwise, all content, including illustrations are exclusive property of Kenhub GmbH, and are protected by German and international copyright laws. All rights reserved.

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