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Vas deferens (ductus deferens)

Recommended video: Testis and epididymis [14:56]
Testes and epididymides are the paired male reproductive organs involved in the production, development and storage of sperm.

The ductus deferens is a muscular tube that is located within the spermatic cord and is a major component of the male reproductive system. It is a continuation of the epididymis and is involved in transporting spermatozoa from the epididymis to the ejaculatory ducts.

The ductus deferens used to be referred to as the vas deferens, however this term in no longer used in modern anatomical nomenclature (due to the fact that this structure is not a vessel, but rather a duct).

This article will talk about the anatomical course, histology, embryology and function of the vas (ductus) deferens, followed by any clinical pathology related to it.

Key facts about the ductus deferens
Course Posterior to testis and medial to epididymis -> inside the spermatic cord -> cross inguinal canal -> exists at deep inguinal ring -> crosses external iliac vessels -> crosses the ureter -> along the bladder -> joins the duct of the seminal vesicle to form the ejaculatory duct
Arterial supply Branch of the superior vesical artery
Venous drainage Testicular vein
Lymphatic drainage Lumbar and external iliac lymph nodes
Histology Pseudostratified columnar epithelium
Function Transport of spermatozoa
  1. Anatomy
    1. Course
    2. Arterial supply
    3. Venous and lymphatic drainage
  2. Histology
  3. Function
  4. Embryology
  5. Clinical notes
    1. Vasectomy
    2. Vasal aplasia
    3. Infections
  6. Sources
+ Show all



The vas (ductus) deferens is 45 cm long and is initially convoluted but becomes straighter as it ascends in its course posterior to the testis and medial to the epididymis. When it reaches the superior aspect of the testis, it travels superiorly in the posterior aspect of the spermatic cord. The vas (ductus) deferens then crosses the inguinal canal before it emerges from the spermatic cord at the deep inguinal ring. It then curves around the inferior epigastric artery and ascends anterior to the external iliac artery. The vas (ductus) deferens then crosses the external iliac vessels in an oblique and slightly posterior direction.

Spermatic cord inside a cadaver: The ductus deferens travels inside the spermatic cord, emerging from it at the deep inguinal ling. The superficial and deep inguinal rings are locations prone to inguinal hernias.The ductus deferens can be easily palpated inside the spermatic cord because it is hard and cord-like.

Following this, it enters the lesser pelvis, where it is retroperitoneal, and traverses medially and posteriorly to the vesical vessels, obturator nerve and vessels, and the obliterated umbilical artery. The vas (ductus) deferens then crosses superior to the ureter at the posterolateral angle of the bladder. Once it crosses the ureter, the vas (ductus) deferens expands and is then referred to as the ampulla of the vas (ductus) deferens. It then passes between the upper aspect of the seminal vesicle and the posterior surface of the bladder in an anteromedial direction.

The vas (ductus) deferens then travels inferiorly along the base of the bladder, anterior to the rectum, before it joins with the duct of the seminal vesicle, at an acute angle, to form the ejaculatory duct.

It's almost time to start revising what you've learned about the ductus deferens. Are you aware of the importance of active recall when it comes to learning anatomy? 

Arterial supply

The vas (ductus) deferens is usually supplied by a branch of the superior vesical artery but is occasionally supplied by a branch of the inferior vesical artery.

Venous and lymphatic drainage

Small veins from the vas (ductus) deferens usually drain into the testicular vein. 

Afferent lymph vessels from the proximal portion of each ductus deferens generally ascends with lymph vessels of the testes to the lumbar lymph nodes. Lymph drained from the intermediate and terminal portion of the ductus deferens however,  mostly drains into the external iliac lymph nodes.

For more information about the ductus deferens, take a look below:


The wall of the vas (ductus) deferens consists of three main layers. The outer layer is comprised of connective tissue whereas the middle layer is comprised of smooth muscle. An inner mucosal layer is also present.

The muscular layer of the vas (ductus) deferens consists of three layers:

  • an inner longitudinal layer
  • a thick intermediate circular layer
  • an outer longitudinal layer

These layers are innervated by the sympathetic nervous system.

The vas (ductus) deferens consists of an inner epithelial lining with supportive lamina propria. The epithelium lining the vas (ductus) deferens is pseudostratified columnar epithelium and is very similar to the epithelium seen in the epididymis. This inner layer is comprised of longitudinal folds, which allows the vas (ductus) deferens to expand during ejaculation.

Practice your newly acquired knowledge about the histology of the ductus deferens by using the following resource:


The vas (ductus) deferens is involved in transporting spermatozoa from the epididymis to the ejaculatory ducts. During ejaculation, the sympathetic nervous system innervates the muscular layers of the vas (ductus) deferens and causes them to produce strong peristaltic contractions in order to aid in the propulsion of the spermatozoa.

If you want to test what you learned so far about the testis and spermatic cord, take our fully customizable quiz that you can fit to your needs!


The vas (ductus) deferens develops from the mesonephric or Wolffian ducts. These ducts are derived from the mesoderm, the middle layer of one of the three primary germ layers in the embryo. The other two layers are the ectoderm and the endoderm. Various male reproductive structures are formed from budding off the mesonephric ducts like the seminal vesicles and the epididymis. After the budding of these structures, the remaining mesonephric ducts develop a muscular coat and form the vas (ductus) deferens.

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