EN | DE | PT Get help How to study Login Register

Arteries of the brain: anterior circulation: want to learn more about it?

Our engaging videos, interactive quizzes, in-depth articles and HD atlas are here to get you top results faster.

What do you prefer to learn with?

“I would honestly say that Kenhub cut my study time in half.” – Read more. Kim Bengochea Kim Bengochea, Regis University, Denver

Arteries of the brain: anterior circulation

The brain has been revered as the most essential organ in the body. It oversees the regulation of physiological homeostasis, executes cognitive functions, and micromanages integral body functions subconsciously.

As a result of the high physiological demand, the brain requires a large volume of blood to execute its daily activities. Although the brain (on average) weighs about 1.2 kg, a grand total of 15% of the cardiac output is utilized by the brain on a daily basis.

The high demand for blood and the high risk of brain injury when the organ is hypoperfused justifies why the brain is such a highly vascular organ. It has a dual supply of blood originating from the internal carotid arteries and the vertebral arteries. These vessels undergo extensive arborisation in order to adequately perfuse the organ.

This topic will be covered in two articles looking at the anterior and posterior divisions of cerebral circulation. Relevant concepts of embryology and the courses of the major arteries arising from the anterior division will be discussed here. Subsequently, the associated clinically significant concepts will be discussed.

Internal carotid artery (lateral-right view)

Embryology of the brain arterial supply

Recall that the processes of vasculogenesis and angiogenesis commence around the third week of gestation (21 days). Vasculogenesis refers to the formation of new vessels from haematoangioblastic stem cells, while angiogenesis speaks to the growth of new blood vessels from existing parent vessels.

There are six pairs of primitive branchial arch arteries that appear during the early stages of development via vasculogenesis; which are integral to the development of the blood supply to the brain. During the third week (around day 24), the internal carotid artery is the first of the cerebral vessels to arise. It is the product of the fusion of the 3rd branchial arch arteries along with the distal components of the dorsal aortae (which is also a paired structure). The ventral pharyngeal artery – which is a derivative of the ventral aspect of the 2nd branchial arch – fuses with the proximal region of the internal carotid artery to form the common carotid artery. For completion, the distal region of the ventral pharyngeal artery continues as the external carotid artery.

During the 4th gestational week, the internal carotid artery bifurcates into the anterior and posterior components. The former will differentiate into the middle cerebral artery, anterior cerebral artery and the anterior choroidal artery; while the latter will form the foetal posterior cerebral artery and the posterior choroidal artery. It should be noted that prior to forming the anterior cerebral and anterior choroidal arteries, the anterior division of the internal carotid artery supplies the olfactory and optic regions of the primitive brain by way of primitive branches.

In the 5th gestational week, a plexiform vascular network originates near the anterior cerebral artery; this is the primitive middle cerebral artery. Although at this point it is not a true artery, it is the primary supplier of blood to the cerebrum. At 6 weeks and 5 days, the plexus fuses to form the adult middle cerebral artery, which subsequently gives off numerous branches to the cerebral hemispheres.

Between the 6th and 7th week of pregnancy, the anterior cerebral artery gives off the olfactory artery before continuing medially in the direction of the opposite anterior cerebral artery. Subsequently, in the 7th week, the anterior communicating artery forms. This process completes the anterior component of the circle of Willis.

Internal carotid artery

Origin and characteristics

The brain receives a dual supply of blood with numerous anastomoses. However, although there is a dual supply, they share a common origin. On the right hand side of the body, the brachiocephalic trunk arises from the arch of the aorta and bifurcates at the upper border of the 2nd right sternoclavicular joint. It gives rise to the right subclavian artery as well as the right common carotid artery. The left counterparts to these vessels are direct derivatives of the aortic arch.

Both the left and right common carotid arteries subsequently bifurcate between the third and fourth cervical vertebra (between the superior horn of the thyroid cartilage and the hyoid bone) to give the internal and external carotid arteries. The internal carotid arteries will serve as the anterior blood supply of the brain.

Internal carotid artery


Traditionally, there were four described parts of the internal carotid artery. There is the cervical part in the neck, the petrous part in the base of the skull, the cavernous part within the cavernous sinus and the intracranial component.

However, the previous Cincinnati Classification (Bouthillier et. al., 1996) has classified the internal carotid artery into seven parts, namely:

  • C1 – Cervical Segment
  • C2 – Petrous Segment
  • C3 – Lacerum Segment
  • C4 – Cavernous Segment
  • C5 – Clinoid Segment
  • C6 – Ophthalmic (Supraclinoid) Segment
  • C7 – Communicating (Terminal) Segment

In the other classification system, C2 and C3 were referred to collectively as the petrous part, and C5, C6, and C7 were referred to as the intracranial components.


The cervical internal carotid artery (C1) has no named branches along its cranial course in the neck. The vessel is slightly dilated at its origin; where it is referred to as the carotid sinus or bulb. It travels superiorly, anterior to the transverse processes of the upper three cervical vertebrae, towards the carotid canal where it becomes the petrous segment (C2).

Carotid sinus (lateral-right view)

The carotid canal traverses the petrous part of the temporal bone. Within the canal, the petrous segment travels superiorly before taking an anteromedial course; after which it travels along a superomedial course. This segment is said to have three parts – an ascending segment, a genu, and a horizontal segment. The internal carotid artery then travels over the cartilage occluding foramen lacerum to become the lacerum segment (C3). This is a short portion of the vessel that ends at the level of the petrolingual ligament (reflected periosteum spanning the petrosal process and lingula of the sphenoid bone). It should be noted that the lacerum segment of the internal carotid artery does not pass through the foramen lacerum; it simply travels above the foramen.

Internal carotid artery (lateral-right view)

At the petrolingual ligament, the cavernous segment (C4) courses superiorly along the posterior clinoid process. Here it travels anteriorly adjacent to the cavernous side of the sphenoid bone before turning medially towards the anterior clinoid process. It finally emerges through the roof of the cavernous sinus. Within the cavernous sinus, the internal carotid artery travels superomedially to CN VI (abducens nerve) and medially to CN III (oculomotor nerve), CN IV (trochlear nerve) CN Va and CN Vb (ophthalmic and maxillary divisions of trigeminal nerve, respectively).

Internal carotid artery (lateral-left view)

The artery exits the cavernous sinus at the proximal dural ring and becomes the clinoid segment (C5). It travels a short distance before becoming the ophthalmic segment (C6) at the distal dural ring. The artery travels parallel and horizontal in an inferolateral position with respect to the optic nerve. The ophthalmic segment ends at the origin of the posterior communicating artery. At this point, the internal carotid artery forms its terminal or communicating segment (C7). It bifurcates into its terminal branches before ending at the anterior perforated substance.

Internal carotid artery (caudal view)


Main branches

Of the seven segments, three are without branches. These are the cervical, lacerum, and clinoid segments. The petrous part gives of the caroticotympanic and Vidian arteries.  The caroticotympanic artery occasionally occurs as a doubled vessel that travels through the tympanic cavity via the foramen within the carotid canal. It subsequently anastomoses with the anterior tympanic branch of the stylomastoid artery and the maxillary artery.

The cavernous segment gives numerous branches to the walls of the cavernous sinus and the surrounding nerves and dura mater. Of significance, the inferior hypophyseal artery originates from this segment of the internal carotid artery. Conveniently, the ophthalmic segment gives of the ophthalmic artery and the superior hypophyseal artery.

Ophthalmic artery

Finally, the communicating segment gives off several major vessels. The posterior communicating artery, which anastomoses with the basilar artery, arises from the C7 segment. The anterior choroidal (supplies mesencephalic, diencephalic, and telencephalic derivatives), anterior cerebral, and middle cerebral arteries also arise from this segment.

Posterior communicating artery (caudal view)

It is undoubtedly easier to remember the old classification. However, here is a quick mnemonic to remember the intracranial segments of the internal carotid artery: Please Let Children Consume Our Candy

  • Please (Petrous – C2)
  • Let (Lacerum – C3)
  • Children (Cavernous – C4)
  • Consume (Clinoid – C5)
  • Our (Ophthalmic – C6)
  • Candy (Communicating – C7)

Terminal branches

The middle cerebral artery is the largest terminal branch of the internal carotid artery. It travels through the Sylvian (lateral) fissure before coursing in a posterosuperior direction on the island of Reil (insula). It subsequently divides to supply the lateral cortical surfaces along with the insula.

Middle cerebral artery (caudal view)

The vessel gives numerous tributaries to both central and cortical regions of the brain. The central branches are relatively small and include the lenticulostriate arteries that pass through the anterior perforated substance to supply the lentiform nucleus and the posterior limb of the internal capsule.

The cortical branches include the frontal, orbital, parietal, and temporal branches. The frontal arteries perfuse the inferior frontal, middle, and precentral gyri. The lateral orbital parts of the frontal lobe as well as the frontal gyrus are supplied by the orbital branches. The inferior parietal lobe, the inferior part of the superior parietal lobe, and the postcentral gyrus receives blood from the parietal branch. Several temporal arteries then go on to perfuse the lateral aspect of the temporal lobe.

Middle cerebral artery and its branches (lateral-right view)

For clinical purposes, the vessel has been subdivided into four parts termed M1 – M4:

  • M1 – also called the sphenoid segment, it continues from the termination of the internal carotid artery to the bifurcation (in some individuals, the vessel trifurcates) of the middle cerebral artery.  
  • M2 – or the insular segment, travels in the Sylvian fissure.
  • M3 – or the opercular portion, begins as the vessel leaves the Sylvian fissure.
  • M4 – refers to the cortical segments of the vessel.

Compared to the middle cerebral artery, the anterior cerebral artery is a much smaller branch of the internal carotid artery. It begins at the terminal portion of the internal carotid artery (after the ophthalmic branch is given off) on the medial part of the Sylvian fissure. It travels in an anteromedial course, superior to CN II towards the longitudinal cerebral fissure. Here it anastomoses with the contralateral counterpart via the short anterior communicating artery. The paired arteries then travel through the longitudinal cerebral fissure in a posterior direction along the genu of the corpus callosum. Here, each vessel anastomoses with the ipsilateral posterior cerebral artery.

Anterior cerebral artery (caudal view)

Like the middle cerebral artery, the anterior cerebral artery also gives off central and cortical branches. The cortical branches, which are named for the regions they supply, are responsible for the somatosensory and motor cortices of the lower limbs. Parietal branches perfuse the precuneus as the orbital branches supply the frontal lobe; olfactory cortex, medial orbital gyrus, and gyrus rectus; and the frontal arteries supply the paracentral lobule, medial frontal and cingulate gyri, and the corpus callosum. The anterior communicating artery has several anteromedial central arteries, which are responsible for supplying the cingulate gyrus, anterior columns of the fornix, hypothalamus lamina terminalis, optic chiasm, and the para-olfactory regions.

Anterior communicating artery (caudal view)

The anterior cerebral artery is also subdivided for clinical purposes into three divisions A1 – A3:

  • A1 – from its origin to the merger with anterior communicating artery.
  • A2 – extending from the branching of anterior communicating artery towards the callosomarginal artery (on the dorsal surface of the corpus callosum).
  • A3 – extending onwards from the branching point of the callosomarginal artery.


  • The brain receives dual supply from the internal carotid artery and the vertebrobasilar system
  • The internal carotid artery can be classified into seven parts based on the Cincinnati Classification as follows:
    • C1 – Cervical Segment
    • C2 – Petrous Segment
    • C3 – Lacerum Segment
    • C4 – Cavernous Segment
    • C5 – Clinoid Segment
    • C6 – Ophthalmic (Supraclinoid) Segment
    • C7 – Communicating (Terminal) Segment
  • The anterior and middle cerebral arteries have both been subdivided into four divisions for clinical purposes.

Infarction and cerebrovascular accidents

Mechanism and symptoms   

Hypo-perfusion of any organ results in a decrease in oxygen and nutrient supply to these tissues. Consequently, if the tissues remain hypoperfused for a prolonged period, they will die. This process is known as an infarction (and the resulting lesion is referred to as an area of infarct). In the brain, infarcted tissue undergoes liquefactive necrosis; as the tissue is digested by enzymes released during tissue damage.

Clinically, the prolonged hypoperfusion manifests as a cerebrovascular accident (stroke). This may be due to an ischaemic process (following a blood clot embolus or a propagating thrombus, for example) or a haemorrhagic process (following rupture of a vessel due to trauma,chronic uncontrolled hypertension, or an arteriovenous malformation). Manifestation of symptoms depends on the vessels that were damaged and the region of the brain that they supply.

The anterior circulation is the site of approximately 70% of cerebral infarcts, with the middle cerebral artery being the offending artery in about 90% of these cases. Lesions of the anterior communicating artery (which supplies the medial surface of the cerebrum) accounts for as little as 2% of cases. Patients may present with sudden manifestations of symptoms or symptoms that developed within 24 hours. The symptoms are often focal and may present with cognitive impairment (impaired speech), unilateral weakness and sensory impairment, and unilateral visual loss. There are other generalized symptoms such as headache, syncope, or in severe cases, seizures and coma.

Types of the infarctions

The anterior circulation can be damaged at different levels, resulting in the manifestation of a variety of symptoms. Lesions of the solitary perforating arteries of the basal ganglia can result in pure sensory, pure motor, or sensory motor strokes, or ataxic hemiparesis. These symptoms are characteristic of lacunar infarcts (LACI). Patients presenting with two of the following symptoms are believed to have suffered an infarct in the middle cerebral artery (M3 or M4) and would be diagnosed with a partial anterior circulation infarct (PACI):

  • Homonymous hemianopia
  • Ipsilateral motor and sensory defects involving more than two-thirds of the legs, face, and arms
  • Cognitive dysfunction characterized by visual and spatial distortion, dysphasia, dyscalculia or decreased level of consciousness

If all three symptoms are present, then it is likely that a total anterior circulation infarct has occurred. In these cases, cortical and central branches of the middle cerebral artery could have been injured.

Arteries of the brain: anterior circulation: want to learn more about it?

Our engaging videos, interactive quizzes, in-depth articles and HD atlas are here to get you top results faster.

What do you prefer to learn with?

“I would honestly say that Kenhub cut my study time in half.” – Read more. Kim Bengochea Kim Bengochea, Regis University, Denver

Show references


  • Bamford, J. et al. "Classification And Natural History Of Clinically Identifiable Subtypes Of Cerebral Infarction". The Lancet, vol 337, no. 8756, 1991, pp. 1521-1526. Elsevier BV, doi:10.1016/0140-6736(91)93206-o.
  • Bouthillier, Alain et al. "Segments Of The Internal Carotid Artery: A New Classification". Neurosurgery, vol 38, no. 3, 1996, pp. 425-433. Oxford University Press (OUP), doi:10.1097/00006123-199603000-00001.
  • Jichici, Draga and Alison Elizabeth Baird. "Anterior Circulation Stroke: Origins And Sites Of Occlusion, Circulatory Anatomy, Ischemic Patterns". Emedicine.Medscape.Com, 2015.
  • Menshawi, Khaled et al. "A Functional Perspective On The Embryology And Anatomy Of The Cerebral Blood Supply". Journal Of Stroke, vol 17, no. 2, 2015, p. 144. Korean Stroke Society, doi:10.5853/jos.2015.17.2.144.
  • Netter, Frank. Atlas Of Human Anatomy. 6th ed., Philadelphia, Elsevier Saunders, 2014,.
  • Osborn, Anne G et al. Diagnostic Cerebral Angiography. 2nd ed., Philadelphia, Lippincott-Raven, 1999,.
  • Standring, Susan and Henry Gray. Gray's Anatomy. 42nd ed., [Edinburgh], Churchill Livingstone/Elsevier, 2008,.
  • Vrselja, Zvonimir et al. "Function Of Circle Of Willis". Journal Of Cerebral Blood Flow & Metabolism, vol 34, no. 4, 2014, pp. 578-584. SAGE Publications, doi:10.1038/jcbfm.2014.7


  • Internal carotid artery (lateral-right view) - Paul Kim
  • Internal carotid artery - Paul Kim
  • Carotid sinus (lateral-right view) - Paul Kim
  • Internal carotid artery (lateral-right view) - Paul Kim
  • Internal carotid artery (lateral-left view) - Paul Kim
  • Internal carotid artery (caudal view) - Paul Kim
  • Ophthalmic artery - Paul Kim
  • Posterior communicating artery (caudal view) - Paul Kim
  • Middle cerebral artery (caudal view) - Paul Kim
  • Middle cerebral artery and its branches (lateral-right view) - Paul Kim
  • Anterior cerebral artery (caudal view) - Paul Kim
  • Anterior communicating artery (caudal view) - Paul Kim
© Unless stated otherwise, all content, including illustrations are exclusive property of Kenhub GmbH, and are protected by German and international copyright laws. All rights reserved.

Register now and grab your free ultimate anatomy study guide!