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Basal ganglia : want to learn more about it?

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Basal ganglia

The basal ganglia or basal nuclei are large masses of grey matter located within the central core of white matter of the cerebral hemispheres. The basal ganglia is composed of the following grey nuclei:

  • Caudate nucleus
  • Lentiform nucleus
  • Amygdaloid nuclear complex (or Amygdala)
  • Claustrum
  • Substantia nigra (within the midbrain)
  • Subthalamic nucleus

The lentiform nucleus is composed of two groups of neuronal soma (grey matter) known as the putamen and globus pallidus. The lentiform and caudate nuclei together constitutes a mass of grey matter, the corpus striatum.

Therefore, the basal ganglia can also be defined as a large mass of grey matter composed of the corpus striatum, amygdala and claustrum, which is situated deep within the white matter of the cerebral hemispheres.

Note that the substantia nigra and the subthalamic nucleus are not included in the above definition because they are usually described by several authors as only having a functional relationship with the basal ganglia.

Gross anatomy

Amygdaloid complex

The amygdala lies in the temporal lobe, close to the temporal pole of the cerebral hemisphere. It lies deep to the uncus (of the cerebral cortex) and is related to the anterior end of the inferior horn of the lateral ventricle (1st and 2nd ventricle).

Amygdaloid body (medial view)


The claustrum is a thin lamina of grey matter that lies lateral to the lentiform nucleus. It is separated from the latter by fibres of the external capsule. Laterally, it is separated by a thin layer of white matter from the cortex of the insula. Connections and functions of the claustrum are unknown.

Subthalamic nucleus

The subthalamic nucleus (STN) is traditionally described as part of the subthalamic region but functionally grouped with the basal nuclei.

The nucleus is shaped like a biconcave lens. It lies between the thalamus above, and the substantia nigra (of midbrain) below. The upper end of the red nucleus is close to it. The subthalamic nucleus is closely related to the zona incerta, the fascicularis lenticularis intervening between the two.

The fibres connecting the subthalamic nucleus to the globus pallidus (part of the corpus striatum) form a bundle called the subthalamic fasciculus which passes through the internal capsule. The subthalamic nucleus produces the excitatory neurotransmitter glutamate and sends excitatory input to the globus pallidus.

Substantia nigra

This is a midbrain structure that is closely linked, functionally, to the basal ganglia. It is considered the mesencephalic grey matter portion of the basal ganglia. It is divided into a reticulata and a compacta part based on the arrangements of neurons within each part. Cells (neurons) making up the substantia nigra compacta (SNc) are very close to one another, while those of the reticulata, that is, substantia nigra reticulata (SNr) are further away from one another.

Substantia nigra (inferior view)

The substantia nigra pars compacta produces the inhibitory neurotransmitter dopamine, which is very significant in maintaining the striatal pathway (the main input pathway of the basal ganglia). There is a fine connection between the substantia nigra pars reticulata and the subthalamic nucleus and the globus pallidus. Through those connections dopaminergic fibres (inhibitory fibres) are sent to the thalamus.

Corpus striatum

As indicated in the introduction, the corpus striatum is composed of the lentiform and caudate nuclei. Hence, the corpus striatum is made up of the putamen, globus pallidus and caudate nucleus.

The corpus striatum has two parts or units, the striatum and the pallidum. The striatum is composed of caudate nucleus and putamen, while the pallidum is made up of the globus pallidus.


This is composed of the globus pallidus and it forms one unit of the corpus striatum. It sends fibres (efferents) to the substantia nigra pars reticulata and to the thalamus, but receives fibres (afferents) from the striatum.


This is the second unit of the corpus striatum which is composed of the caudate nucleus and putamen. It is the main input unit of the basal ganglia, receiving most of the afferents to the basal nuclei.

Striatum is divided into two parts by a white matter tract known as the internal capsule. Those two parts of the striatum are the caudate nucleus and putamen.

There are two types of cell population within the striatum, the spiny projection neurons (also called medium spiny neurons) which constitutes about 90-95% of its neuronal population. The spiny projection neurons are the principal neurons of the striatum that are largely responsible for its functions, and by extension, the functions of the basal ganglia. The spiny projection neurons are GABAergic, which possess receptors for GABA neurotransmitters. Thus, they are classified as inhibitory neurons.

The second cell group within the striatum consists of interneurons. The interneurons make up about 5-10% of the striatal neurons. They are Cholinergic – releasing and using acetylcholine and are classified as excitatory.



The major efferents (outputs) of the basal ganglia are fibres reaching the pallidum from the striatum. There are also fibres from the striatum to the substantial nigra pars reticularis in the midbrain.


Afferents (inputs) to the basal ganglia, which are also the inputs of the striatum, include the following:

  • From the entire cerebral cortex - this is the largest afferent connection of the basal ganglia. The fibres are glutamatergic – releasing the neurotransmitter glutamate to excite the striatum or striatal neurons.
  • From the substantia nigra - fibres arising in the pars compacta of the substantia nigra reach the striatum, forming the nigrostriatal connections. This very important connection of the basal ganglia ensures a continuous supply of dopamine to the striatum. The nigrostriatal fibres are dopaminergic – releasing the neurotransmitter dopamine.
  • From the thalamus - fibres from the thalamus to the basal ganglia form the thalamostriatal connections or the thalamostriatal afferents. Those connections or pathway carry glutamate and thus are glutamatergic.
  • From the reticular formation of the brainstem (specifically from the midbrain) - afferents from the reticular formation are noradrenergic, supplying noradrenaline neurotransmitter to the basal ganglia.

Reticular formation (cross section)

  • From the locus coeruleus - the striatum also receives fibres from the locus coeruleus. Those fibres are serotonergic, supplying serotonin.

Locus coeruleus (posterior view)


There are a growing number of studies focused on the functions of the basal ganglia, as its functions are yet to be fully understood. However, the following are established functions involving the basal nuclei:

  • Planning and modulation of movement pathways
  • The basal nuclei is involved in the control of movement and learning
  • Coordinating motivation with body movement. Specifically, the basal ganglia inhibits individual behavior in a complex social interaction and also inhibits small voluntary movement

Clinical notes

Degeneration of the basal ganglia and consequently, its dysfunction can lead to several neurological conditions including the following:

Parkinson’s disease

Parkinson’s disease results from loss of dopaminergic innervation (loss of the nigrostriatal connection) to the striatum and other basal ganglia structures. It is also referred to as Parkinsonism or Paralysis agitans (shaking palsy). The condition is characterized by rigidity (increased muscle tone), which leads to a stooped posture, a slow shuffling gait, difficulty in speech and a mask like face. Parkinsonism is believed to be due to degenerative changes in the striatum and the substantia nigra. Patients with this disease lack the nigrostriatal afferents to the striatum, and are also deficit of the neurotransmitter, dopamine in their striatum. Parkinson’s disease is also well characterized by hypokinesia (paucity or insufficient movement).

Cerebral palsy

People with cerebral palsy have various motor problems, such as spasticity, paralysis, and even seizures. Spasticity is a condition in which some muscles are abnormally stiff and as a result interfere with normal movement. This is the reason for the unusual hand and arm positions seen in some people with cerebral palsy. Causes may include fetal infection, environmental toxins, or lack of oxygen (hypoxia). Although cerebral palsy tends to remain relatively stable throughout life, there is no cure currently, and is very difficult to deal with for both the person and his or her family.


This is an abnormal movement in which there is an involuntary shaking (tremor) of the hand, head or other parts of the body. Usually the basal ganglia, cerebellum and the subthalamic nucleus are involved. However, intention tremor is also seen in disorders of the cerebellum, in which case, the tremor comes when the individual tries to perform a voluntary movement.

PAP (or athymhormic) syndrome

PAP is characterized by an unusual lack of motivation due to damage to the caudate nucleus. People with PAP also ignore the usual social and moral motivations. Without the motivating influence of the basal ganglia, the frontal lobe simply stops planning for the future. Oddly, they can still respond to external motivation, such as a loved one's request or an authority's command.

Huntington’s disease

Huntington’s disease is a basal ganglia disorder lying at the other end of the spectrum of the basal ganglia disorders. It is a hereditary, progressive, fatal syndrome characterized by hyperkinesia, dyskinesias, dementia, impaired cognitive abilities and disorders of personality.

Huntington’s disease is particularly “insidious”, because its symptoms do not appear until well into adulthood. The most characteristic sign of Huntington’s disease is chorea (involuntary movement of parts of the body, particularly the distal parts of the limbs). The most obvious pathology of the Huntington’s brain is a profound loss of neurons in the corpus striatum and the cerebral cortex. Neuronal degeneration or neuronal loss in the cerebral cortex is usually accompanied by dementia (‘abnormal forgetfulness’) and personality disorders. Hence these conditions are characteristics of Huntington’s disease.

Cognition and behaviour

Most individuals suffering from basal ganglia disorders also suffer deficits of cognition as the disease progresses. The basal ganglia have also been implicated in several disorders of behavior control like:

  • Tourette syndrome
  • Hemiballismus
  • Schizophrenia
  • Obsessive compulsive disorder
  • Attention deficit hypersensitivity disorder (ADHD)

Basal ganglia : want to learn more about it?

Our engaging videos, interactive quizzes, in-depth articles and HD atlas are here to get you top results faster.

What do you prefer to learn with?

“I would honestly say that Kenhub cut my study time in half.” – Read more. Kim Bengochea Kim Bengochea, Regis University, Denver

Show references


  • I. Singh: Textbook of Human neuroanatomy, 7th edition, (2006), p.207 – 213.


  • Amygdaloid body (medial view) - Paul Kim
  • Substantia nigra (inferior view) - Paul Kim
  • Reticular formation (cross section) - Paul Kim
  • Locus coeruleus (posterior view) - Paul Kim
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