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Cavernous Sinus



The human brain is a highly vascular organ responsible for coordinating a myriad of processes throughout the body. Therefore, it is important that a pathway exists to return blood that enters the cranium to systemic circulation. The cavernous sinuses are one of several drainage pathways for the brain that sits in the middle. In addition to receiving venous drainage from the brain, it also receives tributaries from parts of the face. This article will aim to elucidate the structure, components, anatomical relations, and venous tributaries of the cavernous sinus. Additionally, some clinical implications of abnormalities of the sinus will also be highlighted.

Recommended video: Cavernous sinus
Anatomy and function of the cavernous sinus.


The cavernous sinuses are 1 cm wide cavities that extend a distance of 2 cm from the most posterior aspect of the orbit to the petrous part of the temporal bone. They are bilaterally paired collections of venous plexuses that sit on either side of the sphenoid bone. Although they are not truly trabeculated cavities like the corpora cavernosa of the penis, the numerous plexuses, however, give the cavities their characteristic sponge-like appearance.

Cavernous sinus - cranial view

The cavernous sinus is roofed by an inner layer of dura mater that continues with the diaphragma sellae that covers the superior part of the pituitary gland. The roof of the sinus also has several other attachments. Anteriorly, it attaches to the anterior and middle clinoid processes, posteriorly it attaches to the tentorium (at its attachment to the posterior clinoid process). Part of the periosteum of the greater wing of the sphenoid bone forms the floor of the sinus. The body of the sphenoid acts as the medial wall of the sinus while the lateral wall is formed from the visceral part of the dura mater.


Internal Carotid Artery

In addition to the thin walled veins that traverse the cavernous sinus, a lone arterial vessel also uses the area as a conduit. The internal carotid artery (a branch of the common carotid artery) – along with its postganglionic sympathetic plexus from the superior cervical ganglion – gains access to the cavernous sinus posteriorly.

Internal carotid artery - cranial view

As the petrous part of the internal carotid artery leaves the carotid canal, it curves vertically and superiorly above foramen lacerum to enter the cavernous sinus. Here the artery is also referred to as the cavernous part. Within the sinus, the internal carotid artery travels anteriorly, in a horizontal manner until it reaches the anterior limit of the sinus. Here it curves vertically and superiorly to exit the sinus through its roof and become the cerebral part of the internal carotid artery. It is noteworthy that the cavernous part of the internal carotid artery is the only arterial vessel that is completely surrounded by venous networks. This fact is of great clinical significance, which will be discussed later.

Internal carotid artery - lateral-left view

Abducent Nerve

There are also other non-vascular structures that utilize the cavernous sinus as a pathway to their points of supply. Five cranial nerves (CN) use this pathway to gain access to their points of innervation. The first to be discussed is the abducent nerve (CN VI). This motor nerve leave the pons and gains access through the posterior part of the sinus after passing of the apical potion of the petrous temporal bone. It has also been known to access the cavernous sinus by way of the petrosal sinus, adjacent to the clivus.

Abducens nerve - lateral-left view

Within the cavernous sinus, it takes an inferolateral course, relative to the internal carotid artery. It exits the sinus by way of the superior orbital fissure to gain access to the orbit, where it innervates the lateral rectus muscle of the eyeball.

Oculomotor Nerve

The other nerves travelling through the cavernous sinus do so between the endothelial lining and the dura mater of its lateral wall. The most superior of the four nerves in the lateral wall is the oculomotor nerve (CN III). At the posterior aspect of the roof of the cavernous sinus, the free and attached edges of tentorium cerebelli forms a space through which CN III enters the lateral wall of the sinus. It takes an anterior, inferomedial course (relative to the other nerves in the lateral wall) towards the anterior extremity of the sinus.

Oculomotor nerve - lateral-left view

Here it bifurcates into its superior and inferior rami that pass through the superior orbital fissure. Along with sympathetic fibers from the internal carotid plexus, CN III provides motor supply to inferior oblique, levator palpebrae superioris, and the inferior, medial and superior recti muscles.

Trochlear Nerve

The smallest of the cranial nerves, the trochlear nerve (CN IV), enters the posterior aspect of the cavernous sinus after leaving the posterior part of the brainstem and decussating with the same nerve from the opposite side. It continues anteriorly in the lateral wall of the cavernous sinus, inferior to CN III and passes through the superior orbital fissure at the anterior aspect of the sinus. Once in the orbit, CN IV has the responsibility of innervating the muscles of the eyeball that are responsible for inferolateral motions.

Trochlear nerve - lateral-left view

Trigeminal Nerve

Finally, two of the three branches of the trigeminal nerve (CN V) pass through the cavernous sinus. Prior to entering the cavernous sinus, the proximal portion of the nerve lies in Meckel’s cave, where it forms the trigeminal ganglion. After leaving the cave, the mandibular division (CN V3) courses inferiorly to pass through foramen ovale (without entering the cavernous sinus).

Mandibular nerve - lateral-left view

The other two branches, the ophthalmic and the maxillary (CN V1 and CN V2, respectively), travel through the lateral wall of the sinus. Both take courses inferior to CN III and CN IV, however, CN V2 is the most inferior of them all. Both CN V branches in the sinus travels horizontally. CN V2 leaves the sinus via foramen rotundum, while the three branches of CN V1 exit the cranial fossa via the superior orbital fissure. CN V1 and CN V2 are purely sensory and supply specific regions of the face.

Ophthalmic nerve - lateral-left view

In summary, the nerves passing through cavernous sinus are:

  • In the lateral wall from superior to inferior:
  1. oculomotor nerve (CN III)
  2. trochlear nerve (CN IV)
  3. trigeminal nerve (CN V) ophthalmic and maxillary divisions.
  • Traversing the sinus lateral to the ICA:
  1. abducents nerve (CN VI)


There are numerous structures surrounding the cavernous sinus that are noteworthy. Medially, the sinus is adjacent to the lateral walls of the pituitary fossa with the pituitary gland, the sphenoid bone and its air sinus. The cerebral part of the internal carotid artery courses superiorly. Laterally, the medial aspect of the temporal lobe of each hemisphere lies adjacent to the sinus. And posteriosuperiorly, the uncus of the temporal lobe has a relation to the sinus.

Uncus - caudal view


Superior Ophthalmic Vein

The cavernous sinus is an unconventional venous system in the sense that it does not have a unidirectional flow of blood. Owing to the fact that there are no valves in the sinus and its connected veins, the direction of blood flow is dependent on venous pressure.

The cavernous sinus generally has five venous tributaries. The superior ophthalmic vein receives blood from the ethmoidal, nasofrontal, vorticose (drains the ocular choroid), and central retinal veins. It drains into the anterior part of the sinus via the superior orbital fissure.

Superior ophthalmic vein - cranial view

Inferior Ophthalmic Vein

The inferior ophthalmic vein collects blood from the eyelids, lacrimal sac, and some vorticose contributions, as well as the anterior floor and medial wall of the orbit. In addition to draining to the cavernous sinus, it also drains to the pterygoid plexus.

Inferior ophthalmic vein - lateral-left view

Superficial Middle Cerebral Vein

At the point where the internal carotid artery emerges, the superficial middle cerebral vein pierces the roof of the sinus. Here, it drains blood from the cortices that are adjacent to it as it courses through the lateral sulcus.

Superficial middle cerebral vein - cranial view

Middle Meningeal Vein

Finally, branches of the middle meningeal vein may join the sphenoparietal sinus on its way to the cavernous sinus. Before piercing the roof of the sinus, it travels along the edge of the lesser wing of the sphenoid between the layers of dura mater.

Sphenoparietal sinus - cranial view

Hypophyseal Veins

Additionally, efferent hypophyseal veins of both the adenohypophysis and neurohypophysis drain to the cavernous sinus.

Intercavernous Sinuses & Drainage

The left and right cavernous sinuses communicate by way of the anterior and posterior intercavernous sinuses. These vessels travel anteriorly and posteriorly (respectively) around the infundibulum of the pituitary gland, deep to the diaphragma sellae, between the layers of dura mater.

Posterior intercavernous sinus - cranial view

The cavernous sinus in turn drains to the superior and inferior petrosal sinuses. Both sinuses join the sigmoid sinus, which then becomes the internal jugular vein. The internal jugular vein meets with the subclavian vein to become the left (or right) brachiocephalic vein.

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Show references


  • Netter, F. (2014). Atlas of Human Anatomy. 6th ed. Philadelphia: Saunders/Elsevier, pp.55, 73, 87, 104, 105, 149.
  • Sinnatamby, C. and Last, R. (2011). Last's Anatomy. 12th ed. Edinburgh: Churchill Livingstone/Elsevier, pp.443-447.
  • Snell, R. (2010). Clinical Neuroanatomy. 10th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, pp.434, 340, 341, 343, 344, 360.

Author and Layout:

  • Lorenzo Crumbie
  • Catarina Chaves


  • Cavernous sinus - cranial view - Paul Kim
  • Internal carotid artery - cranial view - Paul Kim
  • Internal carotid artery - lateral-left view - Paul Kim
  • Abducens nerve - lateral-left view - Paul Kim
  • Oculomotor nerve - lateral-left view - Paul Kim
  • Trochlear nerve - lateral-left view - Paul Kim
  • Mandibular nerve - lateral-left view - Paul Kim
  • Ophthalmic nerve - lateral-left view - Paul Kim
  • Uncus - caudal view - Paul Kim
  • Superior ophthalmic vein - cranial view - Paul Kim
  • Inferior ophthalmic vein - lateral-left view - Paul Kim
  • Superficial middle cerebral vein - cranial view - Paul Kim
  • Sphenoparietal sinus - cranial view - Paul Kim
  • Posterior intercavernous sinus - cranial view - Paul Kim
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