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Amygdala anatomy

At some point of our lives we all were overwhelmed by fear and heard many bits of advice from our friends such as: “Think rationally, listen to your brain, there is no reason to be afraid!”. Well, after reading this article, you will be able to explain to them that the epicenter of your fear is in the brain itself, and that it is called the amygdala.
 
In this article, we will focus on the anatomy of amygdala, and a wide spectrum of roles that this structure has when it comes to emotional responses, decision-making and memory.

Key facts
Location Within the temporal lobes, medial to the hypothalamus and adjacent to the hippocampus and inferior (temporal) horn of the lateral ventricle.
Nuclei

Basolateral (ventrolateral) group - response to stress, feeding and drinking behaviour

Corticomedial (dorsomedial) group - hunger and eating behaviours

Centromedial group - respiratory and cardiovascular functions

Afferent projections

Olfactory bulb, orbitofrontal cortex, cingulate gyrus, brainistem, basal forebrain, medial thalamus, hypothalamus

Efferent projections Stria terminalis, the ventral amygdalofugal pathway
Lesions Klüver-Bucy syndrome

Location

The amygdala is one of the two almond-shaped groups of nuclei located deep within the temporal lobes, medial to the hypothalamus and adjacent to the hippocampus and inferior (temporal) horn of the lateral ventricle.

In general, the major functions of the amygdala are in strong correlation with unpleasant, aversive stimuli and situations, and consequential reactions to them. These kind of stimuli are of huge biological significance for evolutionary reasons and thus amygdala is one of the most important brain areas for those “primitive” behaviors. 

The majority of the roles that the amygdala plays, are achieved through its major function: the modulation of the hypothalamus via various neuronal pathways.

Nuclei

The amygdaloid body, or just the amygdala, is a subcortical gray matter of the limbic system which is supplied with blood by the anterior choroidal artery. It contains 13 nuclei that are grouped into three functionally different divisions of nuclei:

  • the basolateral group
  • the central group
  • the corticomedial group

Basolateral (Ventrolateral) Group

This group includes the lateral, basal and the accessory basal nucleus. It is large and phylogenetically newer. Functionally, it belongs to the limbic system. It has reciprocal connections to the sensory association areas of the cortex, all four of them (the auditory, visual and somatosensory cortex).

It projects to three different places:

  • Medial dorsal nucleus of the thalamus
  • The basal nucleus (of Meynart)
  • The ventral striatum

This nucleus modulates different functions of the thalamus, such as:

  • Responses to stress
  • Somatic and autonomic reflexes
  • Feeding and drinking behaviour

Corticomedial (Dorsomedial) Group

This group contains the cortical nuclei and nucleus of the lateral olfactory tract. In comparing to the basolateral group, it is smaller, phylogenetically older, and functionally belongs to the olfactory system. It is actually the site of termination of the olfactory fibers that arise from the olfactory bulb. This nucleus projects to the ventromedial nucleus of the hypothalamus and it plays a role in behaviors associated with hunger and eating.

Amygdaloid body - medial view

Centromedial Group

This group is composed of the medial and central nuclei. It is actually a place where basolateral and corticomedial nuclei both project. This nucleus is reciprocally connected to the visceral sensory and autonomic nuclei in the brainstem that are involved in respiratory and cardiovascular functions.
 
Besides these groups of nuclei, there is a separate set of nuclei that couldn't be easily classified into any of these three groups and therefore are listed separately. These include the intercalated cell masses and the amygdalohippocampal area.

Pathways

Εach amygdaloid nucleus receives inputs and sends outputs to multiple yet distinct regions of the brain. These inputs and outputs are called pathways, and depending on whether they are received or sent, these pathways can be afferent and efferent.

Afferent Projections

The basolateral group of nuclei receives impulses from the dorsal and medial thalamus and many cortical areas, such as insula, prefrontal cortex, parahippocampal cortex and temporal cortex. Also, it receives numerous neural fibers from the brainstem.

In any case, it is clear that all of these fibers convey wide spectrum of somatosensory, visual and optical information to the amygdala. For the reason of receiving numerous afferent fibers, basolateral group of nuclei is often referred as the amygdaloid zone of sensory convergence.
All of these impulses received to the basolateral group are then projected to the centromedial group where they are supposed to be arranged and then sent to different motor centers in order to stimulate a reaction to the received information. For that reason, central group is often referred to as the amygdaloid zone of motor divergence.
 
Specifically these are the structures that send fibers to the amygdala:

  • Olfactory bulb
  • Orbitofrontal cortex
  • Cingulate gyrus
  • Basal forebrain
  • Medial thalamus
  • Hypothalamus
  • Brainstem

Amygdaloid body - coronal view

Efferent Projections

It was mentioned before that the principal role of the amygdala is to modulate the activity of the hypothalamus. It does so via two main pathways: the stria terminalis and the ventral amygdalofugal pathway.

The Stria Terminalis

This pathway runs from the centromedial nucleus of the amygdala to the ventromedial nucleus of the hypothalamus. The pathway also carries fibers to the septal nuclei and to the thalamic regions of the brain.

Along with this efferent fibers, the stria terminalis carries fibers projecting from these three areas back to the amygdala. Stria terminalis plays a major role in various types of organism’s responses to stress.
 
When it leaves the centromedial nucleus, most of its fibers lie between the caudate nucleus and thalamus, followed by the vena terminalis. In its entire length, stria terminalis is in relation to the group of neurons called the bed nucleus of the stria terminalis (BNST), whose function will be described later.

The ending fibers of the stria terminalis are spreading in a form of many rays and they are reaching various nuclei of the hypothalamus, such as ventromedial, preoptic, anterior nucleus and lateral hypothalamus. They also form synapses with neurons of the nucleus accumbens, septal nuclei, caudate nucleus and putamen. Since it is connected with the stria medullaris through the septal nuclei, stria terminalis indirectly modulates the brainstem.

The aforementioned BNST is a limbic forebrain structure that receives projections (besides other areas), from the basolateral amygdala, and projects in turn to hypothalamic and brainstem target areas that mediate many of the autonomic and behavioral responses to aversive or threatening stimuli. It is a structure that has different morphology in male comparing to female brain, it is as twice as large in men as in women. For that kind of nuclei, we say they are sexually dimorphic.

Different morphology of the BNST among men and women also define specific differences when it comes to phobias. This is the reason why women are stereotypically thought to be easier to scare in comparing to men. Other functions of the stria terminalis correlate with anxiety in response to threat. It is thought that BNST acts like a relay site within the hypothalamic-pituitary-adrenal axis and modulates its activity in response to acute stress that lasts longer than 10 minutes. It is also thought that it promotes the behavioral inhibition when encountering unfamiliar individuals.

Amygdalofugal Pathway

This pathway is the major efferent pathway of the amygdala. It begins from the centromedial and basolateral nuclei of the amygdaloid complex and carries the fibers to the multiple locations within the nervous system.

The axons from the basolateral group are going medially through the innominate substance, and are ending in the hypothalamus and the septal nuclei. It is known that innominate substance projects cholinergic neurons to the cortex of the brain that are important for the modulation of social behavior. Also, the basolateral group projects fibers that are diffusely spreading and synapsing with wide areas of the frontal and prefrontal cortex, the cortex of the cingulate gyrus, the insula and the temporal cortex. On the other hand, fibers from the centromedial nucleus are directed caudally towards the brainstem, in order to end in the raphe nuclei, along with other structures such as periaqueductal gray and the locus coeruleus. These structures also send their fibers back to the amygdala.
 
The amygdalofugal pathway and the stria terminalis together enable the amygdala to directly control the medial hypothalamus, the lateral hypothalamus and midbrain periaqueductal gray. This pathway is specifically important for associative learning.

Review

By this point, numerous functions of the amygdala have been described. For the purpose of more effective learning, let’s list them all in one place:

First and the supreme role of the amygdala is to modulate hypothalamus. By this, it affects several neural structures and defines some behavioural habits. Here are some of the most important:

  • Phobias
  • Response to the acute stress
  • Control of the autonomic nervous system
  • Mediating memory storage in fear conditioning

Knowing the anatomy of the amygdala, and consequently understanding its functions is something that will enlighten everyone who is passionate about neuroanatomy. Besides fulfilling your knowledge about the general anatomy of the brain, it will introduce you to the phylogenetically ancient structures of the nervous system so you could better understand things that are still a big question mark for the scientists - human emotions.

Lesions of the Amygdala

Knowing the functions of the amygdala is very important, because if your patient has some kind of lesion within the temporal lobe, it will be easy for you to notice if the amygdala is also affected. People with damaged amygdala express symptoms of so called Klüver-Bucy syndrome. This syndrome is defined by the following symptoms:

  • Inability of visual recognition of the surrounding objects
  • Tendency to inspect the surrounding objects by smelling them or chewing them
  • Irresistible need to explore the surrounding space and excessive reactions to visual stimuli
  • Excessive expression of fear and anger
  • Eating abnormal amounts of food even when the patient is not hungry

Along with these symptoms, damage of the amygdala can be followed by amnesia, dementia and aphasia.

Amygdala anatomy - want to learn more about it?

Our engaging videos, interactive quizzes, in-depth articles and HD atlas are here to get you top results faster.

Sign up for your free Kenhub account today and join over 960,586 successful anatomy students.

“I would honestly say that Kenhub cut my study time in half.” – Read more. Kim Bengochea Kim Bengochea, Regis University, Denver

Show references

References:

  • M. A. Patestas, L. P. Gartner: A Textbook of Neuroanatomy, Blackwell Publishing (2006), p. 353-355
  • P. Sah, E. S. L. Faber, J. Power et al.: The Amygdaloid Complex: Anatomy and Physiology, Physiological reviews (2003), volume 83, issue 3, p. 804-822

Article, Review, Layout:

  • Jana Vaskovic
  • Dimitrios Mytilinaios
  • Adrian Rad

Illustrators:

  • Amygdaloid body - medial view - Paul Kim
  • Amygdaloid body - coronal view - Paul Kim
© Unless stated otherwise, all content, including illustrations are exclusive property of Kenhub GmbH, and are protected by German and international copyright laws. All rights reserved.

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