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Foramina and Fissures of the Skull

In this article we will be focusing on the foramina and fissures located on the inside and floor, or base, of the skull. The number of foramina and fissures located in the floor of the skull can be overwhelming upon first look! However, once you understand what they are, what they do, and what structures pass through them, these holes can make learning much more interesting.


The word foramen comes from the Latin word meaning “hole.” Essentially, all of the foramen (singular), or the foramina (plural of foramen), in the skull are holes. They are passageways through the bones of the skull that allow different structures of the nervous and circulatory system to enter and exit the skull.

Overview of base of the skull - superior view

Overview of base of the skull - superior view

In this way, fissures of the skull are very similar to foramina, in that they are also passageways through bone. They are called fissures simply because they are a different shape of hole, they look more like a crack or cleft, and typically occur between separate anatomical structures. For example, the superior orbital fissure lies between the lesser and greater wings of the sphenoid bone. To see the difference between a foramen and a fissure, you can compare the shape of the foramen ovale to the superior orbital fissure. The foramen ovale is smaller and round in shape whereas the superior orbital fissure is quite long and narrow in comparison. Also considered to be types of holes in the skull are structures with canal, hiatus, or meatus in their name.

Learning Strategies

When learning the foramina and fissures of the skull, or anything in anatomy, it is often best to learn them in groups. One way to do this is to learn the foramina and fissures based on the bone in which they are located. Inside the skull however, you can divide the floor or base of the skull into three different shallow depressions known as fossae (anterior, middle, and posterior), and then learn the foramina and fissures associated with each of those.

We will utilize this second strategy throughout this article. In addition, many of the foramina and fissures allow the passage of cranial nerves into or out of the skull, and so it can be helpful to learn the holes starting at the anterior of the skull and moving posteriorly . Using these two strategies will allow us to discuss the foramina and fissures in a logical progression that includes an ascending order relative to the cranial nerves mentioned.

Review of Skull Bones and Fossae

Before starting our discussion of the foramina and fissures, let’s quickly review the bones and fossae that make up the interior floor of the skull. The anterior cranial fossa is made up of parts of the frontal, ethmoid, and sphenoid bones. The middle cranial fossa is made up of parts of the sphenoid, temporal, and parietal bones. The posterior cranial fossa consists mostly of parts of the occipital and temporal bones, and to a smaller extent, the sphenoid and parietal bones also.

Cranial fossae - superior view

Cranial fossae - superior view

Foramina/Fissures of the Anterior Cranial Fossa

There are only two foramina to mention in the anterior cranial fossa, but one is a group of foramina associated with the first of the cranial nerves we will be mentioning.

  • Foramen caecum (or cecum): Is the most anterior of the holes in the floor of the skull. It lies in the frontal bone, just anterior to the ethmoid bone. It allows the passage of an emissary vein that comes from the nasal cavity and drains into the superior sagittal sinus, part of the venous drainage system associated with the brain. In general, emissary veins are veins that drain blood from outside the cranial cavity (in this case from the nose) to inside the cranial cavity via foramina in the skull. Interestingly, this particular emissary vein can be a route for infection to pass from the nose into the cranial cavity!

Foramina of anterior cranial fossa - superior view

Foramina of anterior cranial fossa - superior view

  • Olfactory foramina in the cribriform plate: These holes make up a very important part of the pathway of the first cranial nerve (CNI), the olfactory nerve. Nerve endings in the top of our nose, responsible for our sense of smell, pass through these holes in the cribriform plate of the ethmoid bone. These nerve endings then combine within the cranial cavity on top of the cribriform plate to form the olfactory bulb, and then the olfactory tract which will relay information about what we are smelling to our brain.

Foramina/Fissures of the Middle Cranial Fossa

While there are more holes associated with the middle cranial fossa than either the anterior or posterior cranial fossae, thankfully there is also a mnemonic that may help you remember what the main ones are! Thinking about countries where the winters can be really cold, reminds me of this mnemonic: 'O so frosty!' (Just remember the last two letters aren’t used for any holes) - Note that these follow the progression (anterior to posterior). 

  • Optic canal (O): Lies within the lesser wing of the sphenoid just anterior and medial to the anterior clinoid process of the sphenoid bone. The optic canal allows two very important structures to pass to and from the eye. The ophthalmic artery, which supplies blood to the retina of the eye, and the second cranial nerve (CNII), the optic nerve which sends visual information from the eye to the brain to be interpreted.
  • Superior orbital fissure (SOF): This crack in the middle cranial fossa, that lies just posterior and lateral to the optic canal, can be better appreciated if viewed from the front, as it lies at the back of the eye orbit or socket. As mentioned earlier, a fissure is usually located between two structures, and in this case, the superior orbital fissure is located between the lesser and greater wings of the sphenoid. Superior to the fissure in the orbit is the previously mentioned optic canal. Because it also gives passageway to and from the orbit, the superior orbital fissure also allows important structures to pass to and from the eye. The third cranial nerve (CNIII), the oculomotor nerve, provides nervous input to four out of the six muscles that move the eyeball. The fourth cranial nerve (CNIV), the trochlear nerve, and the sixth cranial nerve (CNVI), the abducent nerve, provide nervous input to the other two muscles that move the eyeball. Also passing through the superior orbital fissure, on its way through the orbit carrying sensory information from the forehead and parts of the face near the eyes, is the fifth cranial nerve (CNV), the trigeminal nerve. More specifically, the first division of the trigeminal nerve known as the ophthalmic nerve, typically written as CNV1. The final structures to pass through the superior orbital fissure are the ophthalmic veins.

Superior orbital fissure and foramen ovale - superior view

Superior orbital fissure and foramen ovale - superior view

  • Foramen rotundum (R): This small round hole lies posterior to the optic canal and the superior orbital fissure on the floor of the skull. It allows the second division of the trigeminal nerve (CNV2), the maxillary nerve, to enter the skull carrying sensory information coming from areas  of the face associated with the region under the eyes, and the upper lip, or the skin overlying the maxilla bone.
  • Foramen ovale (O): This oval shaped hole lies posterior and lateral to the foramen rotundum. The foramen ovale allows passage of the final division of the trigeminal nerve, the mandibular nerve (CNV3). Not surprisingly perhaps, the mandibular nerve enters the skull through the foramen ovale bringing sensory information from the face and skin that overlies the mandible, or lower jaw bone. The foramen ovale also allows passage of the lesser petrosal nerve (a branch of the ninth cranial nerve (CNIX), the glossopharyngeal) which will innervate the parotid gland.

Foramina of middle cranial fossa - superior view

Foramina of middle cranial fossa - superior view

  • Foramen spinosum (S): This foramen is the smallest and most lateral of those found in the middle cranial fossa, and lies posterior and lateral to the foramen ovale. It allows the middle meningeal artery to enter the skull. The middle meningeal artery (a branch of the maxillary artery, which is in turn a branch of the external carotid artery) supplies blood to the dura mater that surrounds the brain.

There are two other foramina in the middle cranial fossa, not covered by the mnemonic mentioned above. They are the:

  • Foramen lacerum: Is located posterior and medial to the foramen ovale, and may be filled with cartilage. It does, however, still allow passage of the greater petrosal nerve, a branch of the seventh cranial nerve (CNVII), the facial nerve. It provides innervation to glands located above the level of the mouth, for example the lacrimal gland near the eye which is associated with tear production.
  • Carotid canal: Lies immediately posterior and lateral to the foramen lacerum. This hole allows the internal carotid artery, one of the major blood supplies to the brain, to enter the skull. Branches of the internal carotid also supply blood to the eye, the contents of the orbit, and the forehead.
Recommended video: Superior view of base of the skull
Structures seen on the superior view of the base of the skull.

Foramina/Fissures of the Posterior Cranial Fossa

Within the posterior cranial fossa, there are four main holes in the floor of the skull. They will be listed in order of the cranial nerves that enter and exit through them, but you may want to remember their location by visualizing where they are in relationship to the largest one, the foramen magnum.

  • Internal acoustic meatus (meatus = passage): Other than the foramen magnum, it is the most anterior of the holes in the posterior cranial fossa. Interestingly, this is one end of a passageway that houses our hearing and balance apparatus. On the other end of this passageway is the external acoustic meatus, or the hole for our ear! There are two cranial nerves that enter the skull through the internal acoustic meatus, the seventh (CNVII), the facial nerve, and the eighth (CNVIII), the vestibulocochlear nerve. The facial nerve has a wide range of functions, including providing nervous input to the muscles of facial expression and taste sensation from the tongue, among others. The vestibulocochlear nerve brings sensory information from our cochlea (part of our hearing apparatus) and from the vestibular canal system contained within the ear.  
  • Jugular foramen: The jugular foramen is also an easier one to locate as its shape is more consistent with a fissure than it is with some of the rounder holes we have been talking about. It allows passage for the ninth (CNIX), tenth (CNX), and eleventh (CNXI) cranial nerves, the glossopharyngeal, the vagus, and the spinal accessory nerve respectively. The function of CNIX is suggested by its name. Glossa is Greek for tongue, and the pharynx is the superior extension of the esophagus and trachea that lies behind the oral and nasal cavities. Its function is then related to the innervation of structures of the tongue and pharynx. The vagus nerve (from the Latin word for vague), so named because its course is vague and wandering as it innervates many of the organs in the abdominal cavity. The spinal accessory nerve (sometimes called simply the accessory nerve) is unique in that it is a cranial nerve that actually arises from the upper segments of the cervical portion of the spinal cord. It then ascends into the skull via the foramen magnum, and then back out through the jugular foramen to supply two muscles in the neck, the sternocleidomastoid and the trapezius. Finally, the jugular foramen allows the vein for which it is named to exit the neck. The internal jugular vein drains much of the blood from the head and parts of the neck down into the brachiocephalic vein and finally to the heart via the superior vena cava.

Foramina of posterior cranial fossa - superior view

Foramina of posterior cranial fossa - superior view

  • Hypoglossal canal: This hole is the one closest to the foramen magnum. It allows passage of the twelfth cranial nerve (CNXII), the hypoglossal nerve. As with the glossopharyngeal, the hypoglossal nerve is associated with the tongue, and provides innervation to all but one of the muscles of the tongue.
  • Foramen magnum: You can’t miss this one! The name in Latin means “great hole” and it has to be relatively large to allow the lower end of the brainstem and the upper end of the spinal cord to pass through. Importantly, the foramen magnum also allows the vertebral arteries to enter the skull. These arteries travel up each side of the spinal column and enter the skull to provide another important supply of blood to the brain.


Provided below, as a summary, is a list of the foramina and fissures, the cranial fossa with which they are associated, and the structures that pass through each hole.

Anterior Cranial Fossa

  • Foramen caecum/cecum: Emissary veins from the nasal cavity
  • Olfactory foramina: Olfactory nerve endings (CNI)

Middle Cranial Fossa

  • Optic canal: Optic nerve (CNII), ophthalmic artery
  • Superior orbital fissure: Oculomotor nerve (CNIII), trochlear nerve (CNIV), ophthalmic division of the trigeminal nerve (CNV1), abducent nerve (CNVI), ophthalmic veins
  • Foramen rotundum: Maxillary division of the trigeminal nerve (CNV2)
  • Foramen ovale: Mandibular division of the trigeminal nerve (CNV3), lesser petrosal nerve
  • Foramen spinosum: Middle meningeal artery
  • Foramen lacerum: Greater petrosal nerve
  • Carotid canal: internal carotid artery

Posterior Cranial Fossa

  • Internal acoustic foramen: Facial nerve (CNVII), Vestibulocochlear nerve (CNVIII)
  • Jugular foramen: Glossopharyngeal nerve (CNIX), vagus nerve (CNX), descending portion of the spinal accessory nerve (CNXI), internal jugular vein
  • Hypoglossal canal: Hypoglossal nerve (CNXII)
  • Foramen magnum: Brainstem/spinal cord, vertebral arteries, ascending portion of the spinal accessory nerve (CNXI)

Clinical Note

Jugular Foramen Syndrome

Jugular foramen syndrome (JFS), also known as Vernet's syndrome is a disorder involving the palsies of the glossopharyngeal, vagus and accessory nerves (cranial nerves IX-XI), as well as sometimes the hypoglossal nerve (CN XII). 

JFS is most often caused by compression of the aforementioned nerves due to some form of jugular foramen mass (i.e. a pathological lesion which arises from, or extends into the jugular fossa). Examples include glomus jugulare tumours, meningiomas, schwannomas and/or inflammatory lesions.

Symptoms of jugular foramen syndrome include:

- hoarseness (dysphonia)

- dysphagia (difficultly swallowing)

- loss of gag reflex

- paralysis of sternocleidomastoid and trapezius muscles

- reduced parotid gland activity

- dropping of the soft palate

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Show references


  • R. L. Drake, A. W. Vogle, A. W. M. Mitchell: Gray’s Clinical Anatomy for Students, 3rd edition, Churchill Livingstone (2015), p. 855-865, 894-900.  
  • M. McKinley, V. D. O’Loughlin: Human Anatomy, 3rd edition, McGraw-Hill (2012), p. 167-168, 176-177, 179, 183, 186-187, 190-192, 195-196, 399
  • K. L. Moore, A. D. Dalley II, A. M. R. Agur: Clinically Oriented ANATOMY, 7th edition, Lippincott Williams & Wilkins (2014), p. 21, 822-833, 835. 
  • K. L. Moore, A. M. R. Agur, A. D. Dalley II: Moore Essential Clinical ANATOMY, 5th edition, Wolters Kluwer (2015), p. 485-492, 627-656.
  • F. H. Netter: Atlas of Human Anatomy, 6th edition, Saunders Elsevier (2014), p. 4-12.


  • Carolyn Perry
  • Francesca Salvador
  • Adrian Rad


  • Overview of base of the skull - superior view - Yousun Koh 
  • Cranial fossae - superior view - Yousun Koh 
  • Foramina of anterior cranial fossa - superior view - Yousun Koh 
  • Superior orbital fissure and foramen ovale - superior view - Yousun Koh
  • Foramina of middle cranial fossa - superior view - Yousun Koh
  • Foramina of posterior cranial fossa - superior view - Yousun Koh
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Related Atlas Images

Inferior view of base of the skull

Superior view of base of the skull


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