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Recommended video: Stomach mucosa and muscle layers [09:09]
Overview of the muscular layers and mucosa of the stomach.

The stomach is an organ of the digestive system, specialized in the accumulation and digestion of food. Its anatomy is quite complex; it consists of four parts, two curvatures and receives its blood supply mainly from the celiac trunk. Innervation is provided via the vagus nerves and the celiac plexus.

Thanks to the stomach, every human is technically capable of corroding metal and picking up new hobbies, such as competitive eating. These are possible due to the extremely potent hydrochloric acid and the expandable nature of this organ.

Key facts about the stomach
Relations Anteriorly: diaphragm, liver (left lobe), and anterior abdominal wall
Posteriorly: omental bursa (lesser sac), pancreas, left kidney and adrenal gland, spleen, and splenic artery
Superiorly: esophagus and diaphragm
Inferiorly and laterally: transverse mesocolon
Parts Cardia, fundus, body, pyloric part
Mnemonic:  Cows Find Bulls Passionate
Functions Mechanical and chemical digestion, absorption, hormone secretion
Layers Mucosa, submucosa, muscularis externa and serosa
Mnemonic:  M.S.M.S
Blood supply Gastric arteries, gastroomental arteries, short gastric arteries, posterior gastric arteries, gastroduodenal artery
Innervation Parasympathetic: vagus nerve (CN X)
Sympathetic: celiac plexus (T5-T12)
Lymphatics Juxtacardial, gastric, short gastric, gastroomental, and pyloric lymph nodes
Drain to celiac nodes →  intestinal lymphatic trunk → cisterna chyli →  thoracic duct
Clinical point Hiatal hernia

In this article we’ll explore every aspect of the stomach mentioned above, including the precise position of the stomach within the abdominal cavity

  1. Anatomy
    1. Location
    2. Parts
    3. Function
  2. Microscopic anatomy
    1. Mnemonic
  3. Blood vessels
  4. Innervation
  5. Lymphatics
  6. Hiatal hernia
  7. Sources
  8. Related articles
+ Show all



The stomach is the most dilated part of the digestive system, lying between the esophagus and duodenum. More precisely, the stomach spans the region between the cardiac and pyloric orifices of the gastrointestinal tract. It is covered and connected to other organs by peritoneum. The lesser omentum connects the stomach to the liver and then extends around the stomach. The greater omentum then continues inferiorly from the stomach, hanging from it like a curtain.The peritoneum has a convoluted course that requires visualization for a complete understanding, so study the following resources to avoid taking a wrong turn. They trace the trajectory of the peritoneum and provide you with an overview of the entire digestive system, including labeling worksheets and a study unit:

The stomach is located inside the abdominal cavity in a small area called the bed of the stomach, onto which the stomach lies when the body is in a supine position, or lying face up. It spans several regions of the abdomen, including the epigastric, umbilical, left hypochondriac, and left flank regions. The stomach also has some precise anatomical relations and comes in contact with several neighboring structures.

Anatomical relations of the stomach
Anteriorly Diaphragm, liver (left lobe), and anterior abdominal wall
Posteriorly Omental bursa (lesser sac), pancreas, left kidney and adrenal gland, spleen, and splenic artery
Superiorly Esophagus and diaphragm
Inferiorly and laterally Transverse mesocolon


The stomach consists of several important anatomical parts. The four main sections of the stomach are the cardia, fundus, body, and pyloric part. As the name implies, the cardia surrounds the cardiac orifice, which is the opening between the esophagus and the stomach. It is the first section that ingested food passes through, representing the inflow part. The fundus is the superior dilation of the stomach, which is located superiorly relative to the horizontal plane of the cardiac orifice. 

Next, we have the corpus, or gastric body, which is the largest part of the organ. Finally, the pyloric part represents the outflow section of the stomach, passing stomach contents into the duodenum. The pylorus is further divided into two distinct areas – the pyloric antrum connected to the stomach and the pyloric canal connected to the duodenum. The contents of the pyloric canal enter into the duodenum via the pyloric orifice, the opening and closing of which are controlled by the pyloric sphincter (pylorus), a circular layer of smooth muscle.

As you might notice in the stomach diagram illustrated above, the organ has a characteristic J-shape created by two unequal curvatures. The longer and convex curvature located on the left of the stomach is called the greater curvature, this starts from the cardiac notch that is formed between the esophageal border and fundus. In contrast, the shorter concave curvature found to the right is the lesser curvature. The latter contains a small notch called the angular incisure which marks the line of intersection between the body and pyloric part of the stomach.


You might be wondering if there's an easy way to remember the parts of the stomach. Of course there is and we're about to tell you! Just remember the phrase ' Cows Find Bulls Passionate', which stands for:

  • Cardium
  • Fundus
  • Body
  • Pylorus

Now to cement your newly acquired knowledge about the parts of the stomach take a look at the following study quiz!


The main function of the stomach involves mechanical and chemical digestion of ingested food. Ingested food enters the stomach from the esophagus via the cardiac orifice, falling into gastric juice produced by the stomach. Repetitive muscle contractions physically churn food particles, breaking them into smaller fragments which are mixed with the gastric juice. The various enzymes and hydrochloric acid (pH 1-2) in the gastric juice break food down even more, forming a semi-liquid substance called chyme. This ultimately passes into the duodenum through the pyloric orifice by a process called gastric peristalsis. Being a muscular organ, the stomach can distend quite a lot, accumulating anywhere between 2 and 3 liters of food.

Looking for a Kenhub app? You don't need one! The Kenhub website is fully responsive across all electronic devices, so you can easily learn about the anatomy of the stomach anywhere by simply continuing to read this page!

In addition to digestion, this organ is also involved in a small degree of absorption. Specifically, it can absorb water, caffeine, and a small proportion of ingested ethanol. The stomach also plays a role in controlling secretion and motility within the digestive tract by releasing several hormones such as gastrin, cholecystokinin, secretin, and gastric inhibitory peptide.

Microscopic anatomy

So far, we’ve seen the external, macroscopic structure of the stomach. Let’s dive deeper to see its internal and microscopic structure. The stomach consists of four histological layers called, from interior to exterior, mucosa, submucosa, muscularis externa, and serosa

When the stomach is empty or contains very small quantities of food, it is in a contracted, shrunken state. The mucosa has a wrinkled aspect, consisting of ridges called gastric folds, or rugae. During distension of the organ, the gastric folds disappear. Along the lesser curvature of the stomach, a temporary, continuous furrow called gastric canal is formed between the gastric folds. This facilitates the passage of saliva and fluids during swallowing.

The mucosa is lined by simple columnar epithelium which is covered by a protective, alkaline mucous layer. The epithelial layer contains numerous invaginations, called gastric pits, that extend deeper into structures called gastric glands. Depending on the part of the stomach, these glands consist of various cell types. Mucous neck cells produce the mucous layer, while parietal cells secrete hydrochloric acid. Chief cells release pepsinogen, an inactive precursor that will transform into the active pepsin enzyme in a low pH environment. In turn, neuroendocrine cells release various hormones mentioned previously.

Moving externally, the next layer is the submucosa. It consists of loose connective tissue containing blood vessels and nerves.

The third layer is called muscularis externa and consists of three smooth muscle sub-layers. From internal to external, they are called inner oblique, middle circular, and external longitudinal. The inner oblique layer is located throughout the entire organ and works in unison with the other layers to produce the physical motion and contractions of the stomach required for digestion. The middle circular layer is located concentrically to the long axis of the stomach throughout the organ and plays an important role in forming the pyloric sphincter. The external longitudinal layer is situated in the two curvatures of the stomach in a longitudinal fashion. Last but not least, the serosa consists of the visceral peritoneum that covers the stomach.

Test your knowledge on the microanatomy of the stomach with our quiz.


You can easily remember the layers of the stomach wall using a mnemonic. ' M.S.M.S', which stands for:

  • Mucosa
  • Submucosa
  • Muscularis externa
  • Serosa

Blood vessels

The overall blood supply of the stomach originates from the abdominal aorta and is provided from two anastomotic systems along the curvatures and several direct branches. The anastomosis along the lesser curvature is created by the union of the right and left gastric arteries which originate from the common hepatic artery and celiac trunk respectively. The greater curvature anastomosis is formed by the union of the right and left gastroomental arteries (gastroepiploic), which originate from the gastroduodenal and splenic arteries respectively.

The splenic artery also sends out short and posterior gastric arteries, which directly supply the fundus and upper body of the stomach. The pyloric part receives arterial blood from the gastroduodenal artery, which stems from the common hepatic artery. The veins draining the stomach follow the course and nomenclature of the arteries very closely. They ultimately drain into three large vessels called the hepatic portal, splenic, and superior mesenteric veins

Do you want to find out how every blood vessels twists and turns as it snails towards its respective gastric portion?


The stomach receives involuntary innervation by the autonomic nervous system (ANS). Parasympathetic innervation originates from the anterior and posterior vagal trunks, which stem from the left and right vagus nerves (CN X), respectively. The anterior vagal trunk mainly supplies a portion of the anterior surface of the stomach, as well as the pylorus. The larger posterior vagal trunk innervates the remaining anterior surface, as well as the entire posterior surface. Parasympathetic innervation is responsible for inducing gastric secretion and motility, as well as relaxation of the pyloric sphincter during gastric emptying. The vagus nerves also carry sensations of pain, fullness, and nausea from the stomach.

In contrast, sympathetic innervation is provided by the celiac plexus. The nerve impulses originate from the fifth to twelfth thoracic spinal nerves (T5-T12) and travel to the celiac plexus via the greater splanchnic nerves. Sympathetic innervation is responsible for inhibiting gastric motility and constricting the pyloric sphincter, thus preventing gastric emptying.


The lymphatic drainage of the stomach is variable between individuals but the same regional lymph nodes are generally involved. These are the:

  • juxtacardial nodes (a.k.a. paracardial nodes),
  • gastric nodes (of which there are left and right, corresponding to the left and right gastric arteries),
  • short gastric nodes (corresponding to the short gastric arteries)
  • gastroomental nodes (a.k.a. gastroepiploic, of which there are left and right following the arteries of the same names),
  • pyloric nodes (made up of the supra-, infra- (or sub-) and retropyloric groups).

These groups drain into the celiac nodes which drain through the intestinal lymphatic trunk into the cisterna chyli (if present) and from there flow into the thoracic duct. Some drainage will often occur from the stomach to the splenic and superior mesenteric nodes.

For more about the lymphatic drainage of the stomach take a look at the following resources:

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